Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer

Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer

Summary: During chronic viral infection and cancer, it has been established that a subset of progenitor CD8+ T cells continuously gives rise to terminally exhausted cells and cytotoxic effector cells. Although multiple transcriptional programs governing the bifurcated differentiation trajectories ha...

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Bibliographic Details
Main Authors: Arjun Kharel, Jian Shen, Ryan Brown, Yao Chen, Christine Nguyen, Donia Alson, Theresa Bluemn, Jie Fan, Kexin Gai, Bin Zhang, Matthew Kudek, Nan Zhu, Weiguo Cui
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006605

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