Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments
On the model of systemic inflammatory response syndrome caused by toxi-allergic myocarditis 10-day duration in rabbits the efficacy of 5 days (beginning after 5 days from the injection of staphylococcus toxins) administration of the various pharmacological agents on the endotoxemia intensity has bee...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2015-12-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/422 |
| _version_ | 1797295526675218432 |
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| author | D. I. Ionov M. M. Fedorova G. V. Sukoyan P. A. Galenko-Yaroshevsky N. V. Gongadze |
| author_facet | D. I. Ionov M. M. Fedorova G. V. Sukoyan P. A. Galenko-Yaroshevsky N. V. Gongadze |
| author_sort | D. I. Ionov |
| collection | DOAJ |
| description | On the model of systemic inflammatory response syndrome caused by toxi-allergic myocarditis 10-day duration in rabbits the efficacy of 5 days (beginning after 5 days from the injection of staphylococcus toxins) administration of the various pharmacological agents on the endotoxemia intensity has been studied. It has been shown that pathological shifts in cytokine system in myocardium occurs early than in blood. The efficacy of action of the studding cardiotonic drug on the endotoxemia were: Adenocin® > amrinone ≥ digoxin > levosimendan. Influence of Adenocin®, and in less extent digoxin unlike amrinone and levosimendan, leads to the decreasing in the expression of nuclear transcription factor NF-kB and expression of intercellular adhesion molecule-1 (ICAM-1). |
| first_indexed | 2024-03-07T21:50:11Z |
| format | Article |
| id | doaj.art-29f7781373c34e66be52f6d70847447a |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:50:11Z |
| publishDate | 2015-12-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-29f7781373c34e66be52f6d70847447a2024-02-25T10:57:17ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442015-12-016636810.25207/1608-6228-2015-6-63-68422Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experimentsD. I. Ionov0M. M. Fedorova1G. V. Sukoyan2P. A. Galenko-Yaroshevsky3N. V. Gongadze4Kuban state medical universityRussian academy of postgraduate study ministry of health and social developmentInternational scientific-research centre of introduction and development of new biomedical technologyKuban state medical universityInternational scientific-research centre of introduction and development of new biomedical technologyOn the model of systemic inflammatory response syndrome caused by toxi-allergic myocarditis 10-day duration in rabbits the efficacy of 5 days (beginning after 5 days from the injection of staphylococcus toxins) administration of the various pharmacological agents on the endotoxemia intensity has been studied. It has been shown that pathological shifts in cytokine system in myocardium occurs early than in blood. The efficacy of action of the studding cardiotonic drug on the endotoxemia were: Adenocin® > amrinone ≥ digoxin > levosimendan. Influence of Adenocin®, and in less extent digoxin unlike amrinone and levosimendan, leads to the decreasing in the expression of nuclear transcription factor NF-kB and expression of intercellular adhesion molecule-1 (ICAM-1).https://ksma.elpub.ru/jour/article/view/422сердечная недостаточностьсиндром системного воспалительного ответакардиотонические средстваэндотоксемиявнутриклеточная молекула адгезииheart failuresystemic inflammatory response syndromecardiotonic drugendotoxemiaintercellular adhesion molecule-1 |
| spellingShingle | D. I. Ionov M. M. Fedorova G. V. Sukoyan P. A. Galenko-Yaroshevsky N. V. Gongadze Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments Кубанский научный медицинский вестник сердечная недостаточность синдром системного воспалительного ответа кардиотонические средства эндотоксемия внутриклеточная молекула адгезии heart failure systemic inflammatory response syndrome cardiotonic drug endotoxemia intercellular adhesion molecule-1 |
| title | Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments |
| title_full | Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments |
| title_fullStr | Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments |
| title_full_unstemmed | Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments |
| title_short | Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments |
| title_sort | efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments |
| topic | сердечная недостаточность синдром системного воспалительного ответа кардиотонические средства эндотоксемия внутриклеточная молекула адгезии heart failure systemic inflammatory response syndrome cardiotonic drug endotoxemia intercellular adhesion molecule-1 |
| url | https://ksma.elpub.ru/jour/article/view/422 |
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