Effectiveness of Insulin Glargine on Recovery of Patients with Diabetic Ketoacidosis: A Randomized Controlled Trial
Background: Diabetic Ketoacidosis (DKA) is a major hyperglycemic emergency in diabetes mellitus (DM). The basic treatment is injection of Regular insulin (RI). This study was aimed to investigate the effects of insulin Glargine (GI) on recovery of patients with DKA. Materials and Methods: A ran...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5883/12005_CE[Ra_Ash]_F(P)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: Diabetic Ketoacidosis (DKA) is a major
hyperglycemic emergency in diabetes mellitus (DM). The
basic treatment is injection of Regular insulin (RI). This study
was aimed to investigate the effects of insulin Glargine (GI) on
recovery of patients with DKA.
Materials and Methods: A randomized clinical trial conducted
on 40 patients (twenty patients in each group) with DKA. Both
groups received standard treatment for DKA. Experimental
group was given 0.4U/kg of GI within three hours of initiation of
IV insulin infusion.
Results: The mean duration of acidosis correction time and
recovery from DKA was 13.77±6.10 and 16.91±6.49 h in the
intervention and control groups respectively (p=0.123). The
mean dosage of RI until recovery from DKA was 84.8±45.6 in
the intervention and 116.5±91.6 units in control groups (p=0.17).
Hypokalemia occurred in three patients in intervention and four
patients in control groups. In 35% of samples in intervention
group and 51% in controls blood sugar was more than 10
mmol/l for 24 h after discontinuation of the insulin infusion
(p=0.046). The mean duration of hospitalization was 5.1±1.88 in
intervention and 5.9±2.19 d in control group (p=0.225).
Conclusion: Adding GI to the standard treatment of DKA
reduced average time of recovery from DKA, without incurring
episodes of hypoglycemia and hypokalemia. This also reduced
in the time of recovery from DKA, amount of required insulin and
the duration of hospitalization. It seems that the non-significant
difference in the time of recovery from DKA be related to
the small sample size and study design. Further studies are
recommended. |
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| ISSN: | 2249-782X 0973-709X |