Lipopolysaccharide‐induced hypothalamic inflammation in cancer cachexia‐anorexia is amplified by tumour‐derived prostaglandin E2

Lipopolysaccharide‐induced hypothalamic inflammation in cancer cachexia‐anorexia is amplified by tumour‐derived prostaglandin E2

Abstract Background Cachexia‐anorexia syndrome is a complex metabolic condition characterized by skeletal muscle wasting, reduced food intake and prominent involvement of systemic and central inflammation. Here, the gut barrier function was investigated in pancreatic cancer‐induced cachexia mouse mo...

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Bibliographic Details
Main Authors: Xiaolin Li, Tosca Holtrop, Fleur A.C. Jansen, Brennan Olson, Pete Levasseur, Xinxia Zhu, Mieke Poland, Winni Schalwijk, Renger F. Witkamp, Daniel L. Marks, Klaske vanNorren
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Hypothalamic inflammation
Prostaglandin
Gut–brain axis
Cancer
Cachexia
Online Access:https://doi.org/10.1002/jcsm.13093

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