Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers
Aim: The aim of this study was to investigate the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) levels in children with inactive hepatitis B virus (HBV) carriers and to evaluate the possible association between NLR, MPV and inflammation status in HBV infection.Material and Meth...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Mustafa Kemal University
2015-07-01
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| Series: | Mustafa Kemal Üniversitesi Tıp Dergisi |
| Subjects: | |
| Online Access: | http://dergipark.gov.tr/mkutfd/issue/19601/209466?publisher=mku |
| _version_ | 1797906226378440704 |
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| author | Unal Uluca Velat Sen Ali Gunes Ilhan Tan Fesih Aktar Ercan Cubuk Muhammed Sabaz |
| author_facet | Unal Uluca Velat Sen Ali Gunes Ilhan Tan Fesih Aktar Ercan Cubuk Muhammed Sabaz |
| author_sort | Unal Uluca |
| collection | DOAJ |
| description | Aim: The aim of this study was to investigate the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) levels in children with inactive hepatitis B virus (HBV) carriers and to evaluate the possible association between NLR, MPV and inflammation status in HBV infection.Material and Method: Thirty inactive HBV carrier children and 32 age and gender matched healthy controls were enrolled as study group. Complete blood count parameters including white blood count, absolute neutrophil count and lymphocyte count, neutrophil to lymphocyte ratio and mean platelet volume were assessed in both study and the control groups.Results: There was no significant difference in the mean age of inactive HBV carriers (11.9±3.4 years) and the control subjects (11.0±2.7 years) (p=0.25). No significant differences were found in NLR (2.90±3.24 and 1.74±0.87, respectively, p=0.82) and MPV levels (7.9±1.0fL and 8.0±1.2fL, respectively, p=0.86) between inactive HBV carriers and the controls. MPV was found to be inversely correlated with platelet count in both patients and the control groups (r=-0.44, p=0.01; r=-0.36, p=0.04, respectively). A positive correlation was found between NLR and MPV (r=0.41, p=0.03) in patient group.Conclusion: NLR and MPV levels were not different in inactive HBV carrier children compared to the controls. Our results suggest that NLR and MPV values may not be appropriate for determining of chronicity and inflammation status in chronic HBV infection.Key words: Hepatitis B, chronic, neutrophil to lymphocyte ratio, mean platelet volume |
| first_indexed | 2024-04-10T10:17:35Z |
| format | Article |
| id | doaj.art-29fb8c62272e4b08acf6f68f158b405b |
| institution | Directory Open Access Journal |
| issn | 2149-3103 |
| language | English |
| last_indexed | 2024-04-10T10:17:35Z |
| publishDate | 2015-07-01 |
| publisher | Mustafa Kemal University |
| record_format | Article |
| series | Mustafa Kemal Üniversitesi Tıp Dergisi |
| spelling | doaj.art-29fb8c62272e4b08acf6f68f158b405b2023-02-15T16:21:47ZengMustafa Kemal UniversityMustafa Kemal Üniversitesi Tıp Dergisi2149-31032015-07-0162281310.17944/mkutfd.75063102Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B CarriersUnal UlucaVelat SenAli GunesIlhan TanFesih AktarErcan CubukMuhammed SabazAim: The aim of this study was to investigate the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) levels in children with inactive hepatitis B virus (HBV) carriers and to evaluate the possible association between NLR, MPV and inflammation status in HBV infection.Material and Method: Thirty inactive HBV carrier children and 32 age and gender matched healthy controls were enrolled as study group. Complete blood count parameters including white blood count, absolute neutrophil count and lymphocyte count, neutrophil to lymphocyte ratio and mean platelet volume were assessed in both study and the control groups.Results: There was no significant difference in the mean age of inactive HBV carriers (11.9±3.4 years) and the control subjects (11.0±2.7 years) (p=0.25). No significant differences were found in NLR (2.90±3.24 and 1.74±0.87, respectively, p=0.82) and MPV levels (7.9±1.0fL and 8.0±1.2fL, respectively, p=0.86) between inactive HBV carriers and the controls. MPV was found to be inversely correlated with platelet count in both patients and the control groups (r=-0.44, p=0.01; r=-0.36, p=0.04, respectively). A positive correlation was found between NLR and MPV (r=0.41, p=0.03) in patient group.Conclusion: NLR and MPV levels were not different in inactive HBV carrier children compared to the controls. Our results suggest that NLR and MPV values may not be appropriate for determining of chronicity and inflammation status in chronic HBV infection.Key words: Hepatitis B, chronic, neutrophil to lymphocyte ratio, mean platelet volumehttp://dergipark.gov.tr/mkutfd/issue/19601/209466?publisher=mku-Hepatitis B chronic neutrophil to lymphocyte ratio mean platelet volumeHepatit B kronisite nötrofil-lenfosit oranı ortalama trombosit hacmi |
| spellingShingle | Unal Uluca Velat Sen Ali Gunes Ilhan Tan Fesih Aktar Ercan Cubuk Muhammed Sabaz Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers Mustafa Kemal Üniversitesi Tıp Dergisi - Hepatitis B chronic neutrophil to lymphocyte ratio mean platelet volume Hepatit B kronisite nötrofil-lenfosit oranı ortalama trombosit hacmi |
| title | Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers |
| title_full | Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers |
| title_fullStr | Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers |
| title_full_unstemmed | Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers |
| title_short | Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers |
| title_sort | evaluation of neutrophil to lymphocyte ratio and mean platelet volume in inactive hepatitis b carriers |
| topic | - Hepatitis B chronic neutrophil to lymphocyte ratio mean platelet volume Hepatit B kronisite nötrofil-lenfosit oranı ortalama trombosit hacmi |
| url | http://dergipark.gov.tr/mkutfd/issue/19601/209466?publisher=mku |
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