Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years
IntroductionStarting in December 2021, the Indonesian Government has recommended inactivated SARS-CoV-2 vaccine (CoronaVac) for children aged 6–11 years. This study aims to determine the prevalence and determinant factors of adverse events following immunization (AEFI) of the first dose and the seco...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.999354/full |
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| author | Fitriana Puspitarani Mei Neni Sitaresmi Riris Andono Ahmad Riris Andono Ahmad |
| author_facet | Fitriana Puspitarani Mei Neni Sitaresmi Riris Andono Ahmad Riris Andono Ahmad |
| author_sort | Fitriana Puspitarani |
| collection | DOAJ |
| description | IntroductionStarting in December 2021, the Indonesian Government has recommended inactivated SARS-CoV-2 vaccine (CoronaVac) for children aged 6–11 years. This study aims to determine the prevalence and determinant factors of adverse events following immunization (AEFI) of the first dose and the second dose of the COVID-19 vaccine among children aged 6–11 years old.Materials and methodsWe conducted a cross-sectional study in Bantul District, Yogyakarta, Indonesia, in February–March 2022. Data were collected by trained interviews with 1,093 parents of children 6–11 years old who received the first dose and the second dose of the COVID-19 vaccine. Data were analyzed with chi-square and logistic regression.ResultsThe prevalence of AEFI in the first dose of the COVID-19 vaccine was 16.7%, while the second dose was 22.6%. The most common symptoms of AEFI at the first dose were local site pain and fever, while at the second dose were cough and cold. Determinants of AEFI of COVID-19 vaccination among children were girls with OR 1.31 (95% CI 1.0–1.7; P 0.04), mass-setting of vaccination with OR 0.70 (95% CI 0.5–0.9; P 0.01), the history of AEFI in childhood vaccination with OR 1.63 (95% CI 1.2–2.2; P < 0.01) and administering other vaccines within 1 month before COVID-19 vaccination, with OR 5.10 (95% CI 2.1–12.3 P < 0.01).ConclusionThe prevalence of AEFI in the first and the second dose of inactivated COVID-19 vaccine was comparable to that reported in the clinical trial study and the communities. Risk communication should be provided to the child and their parents regarding the risk of mild AEFI of the COVID-19 vaccine, especially for children with a history of AEFI in childhood vaccination and who received other vaccines containing the same adjuvant with CoronaVac within 1 month. A mass-setting of vaccination should be taken as an advantage to educate parents about the risk of AEFI and also about the reporting pathways. |
| first_indexed | 2024-04-11T19:42:30Z |
| format | Article |
| id | doaj.art-29fdbee9f31243949537a1cb028d4cee |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T19:42:30Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-29fdbee9f31243949537a1cb028d4cee2022-12-22T04:06:39ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.999354999354Adverse events following immunization of COVID-19 vaccine among children aged 6–11 yearsFitriana Puspitarani0Mei Neni Sitaresmi1Riris Andono Ahmad2Riris Andono Ahmad3Department of Biostatistics, Epidemiology, and Population Health, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, IndonesiaDepartement of Child Health, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, DR. Sardjito Hospital, Yogyakarta, IndonesiaDepartment of Biostatistics, Epidemiology, and Population Health, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, IndonesiaCenter for Tropical Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, IndonesiaIntroductionStarting in December 2021, the Indonesian Government has recommended inactivated SARS-CoV-2 vaccine (CoronaVac) for children aged 6–11 years. This study aims to determine the prevalence and determinant factors of adverse events following immunization (AEFI) of the first dose and the second dose of the COVID-19 vaccine among children aged 6–11 years old.Materials and methodsWe conducted a cross-sectional study in Bantul District, Yogyakarta, Indonesia, in February–March 2022. Data were collected by trained interviews with 1,093 parents of children 6–11 years old who received the first dose and the second dose of the COVID-19 vaccine. Data were analyzed with chi-square and logistic regression.ResultsThe prevalence of AEFI in the first dose of the COVID-19 vaccine was 16.7%, while the second dose was 22.6%. The most common symptoms of AEFI at the first dose were local site pain and fever, while at the second dose were cough and cold. Determinants of AEFI of COVID-19 vaccination among children were girls with OR 1.31 (95% CI 1.0–1.7; P 0.04), mass-setting of vaccination with OR 0.70 (95% CI 0.5–0.9; P 0.01), the history of AEFI in childhood vaccination with OR 1.63 (95% CI 1.2–2.2; P < 0.01) and administering other vaccines within 1 month before COVID-19 vaccination, with OR 5.10 (95% CI 2.1–12.3 P < 0.01).ConclusionThe prevalence of AEFI in the first and the second dose of inactivated COVID-19 vaccine was comparable to that reported in the clinical trial study and the communities. Risk communication should be provided to the child and their parents regarding the risk of mild AEFI of the COVID-19 vaccine, especially for children with a history of AEFI in childhood vaccination and who received other vaccines containing the same adjuvant with CoronaVac within 1 month. A mass-setting of vaccination should be taken as an advantage to educate parents about the risk of AEFI and also about the reporting pathways.https://www.frontiersin.org/articles/10.3389/fpubh.2022.999354/fullAEFICOVID-19 vaccinechildrenprevalencedeterminant factors |
| spellingShingle | Fitriana Puspitarani Mei Neni Sitaresmi Riris Andono Ahmad Riris Andono Ahmad Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years Frontiers in Public Health AEFI COVID-19 vaccine children prevalence determinant factors |
| title | Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years |
| title_full | Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years |
| title_fullStr | Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years |
| title_full_unstemmed | Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years |
| title_short | Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years |
| title_sort | adverse events following immunization of covid 19 vaccine among children aged 6 11 years |
| topic | AEFI COVID-19 vaccine children prevalence determinant factors |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.999354/full |
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