Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis
Abstract Background Although immunoglobulin E (IgE) increases significantly in tears and serum during seasonal allergic conjunctivitis (SAC), it is unclear whether tear total IgE can reflect the severity and prognosis of SAC more accurately than serum total IgE. We aimed to investigate the usefulnes...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Clinical and Translational Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/clt2.12139 |
| _version_ | 1818059295517835264 |
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| author | Jiayu Bao Lei Tian Yifan Meng Binge Wu Jingyi Wang Jing He Qiyan Shao Chengshuo Wang Ying Jie Luo Zhang |
| author_facet | Jiayu Bao Lei Tian Yifan Meng Binge Wu Jingyi Wang Jing He Qiyan Shao Chengshuo Wang Ying Jie Luo Zhang |
| author_sort | Jiayu Bao |
| collection | DOAJ |
| description | Abstract Background Although immunoglobulin E (IgE) increases significantly in tears and serum during seasonal allergic conjunctivitis (SAC), it is unclear whether tear total IgE can reflect the severity and prognosis of SAC more accurately than serum total IgE. We aimed to investigate the usefulness of measuring the total IgE in tears to evaluate the severity and determine the treatment of SAC. Methods This prospective, nonrandomized study involved 55 patients with SAC and 10 age‐ and sex‐matched healthy controls. Serum and tears were collected before and after treatment to analyze the total IgE. SAC patients received the same topical anti‐allergy treatment and were followed‐up every 2 weeks for 1 month. The relationship of tear and serum total IgE concentrations with pollen concentrations and symptom severity before and after treatment was assessed. Results The total IgE concentration in tears was higher in SAC patients than in healthy participants with significant correlations between tear and serum total IgE concentrations. The total IgE concentration in tears, but not in serum, correlated with the pollen concentration and severity of ocular symptoms and reactions in SAC. Treatment‐associated improvements in symptoms and reactions in SAC correlated with decreased concentrations of the tear total IgE. Patients with disease recurrence following treatment demonstrated significantly higher tear total IgE concentrations than patients with no recurrence. Conclusion The total tear IgE level can indicate the severity and predict the prognosis of SAC more accurately than the serum total IgE. |
| first_indexed | 2024-12-10T13:14:15Z |
| format | Article |
| id | doaj.art-29ff3501d97d4f178df5175b6dcb5c30 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-12-10T13:14:15Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-29ff3501d97d4f178df5175b6dcb5c302022-12-22T01:47:36ZengWileyClinical and Translational Allergy2045-70222022-03-01123n/an/a10.1002/clt2.12139Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitisJiayu Bao0Lei Tian1Yifan Meng2Binge Wu3Jingyi Wang4Jing He5Qiyan Shao6Chengshuo Wang7Ying Jie8Luo Zhang9Beijing Institute of Ophthalmology Beijing TongRen Eye Center Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital Capital Medical University Beijing ChinaBeijing Institute of Ophthalmology Beijing TongRen Eye Center Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital Capital Medical University Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaDepartment of Ophthalmology the Second Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology Beijing ChinaBeijing Institute of Ophthalmology Beijing TongRen Eye Center Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital Capital Medical University Beijing ChinaDepartment of Ophthalmology the Second Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology Beijing ChinaDepartment of Ophthalmology the Second Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaBeijing Institute of Ophthalmology Beijing TongRen Eye Center Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital Capital Medical University Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaAbstract Background Although immunoglobulin E (IgE) increases significantly in tears and serum during seasonal allergic conjunctivitis (SAC), it is unclear whether tear total IgE can reflect the severity and prognosis of SAC more accurately than serum total IgE. We aimed to investigate the usefulness of measuring the total IgE in tears to evaluate the severity and determine the treatment of SAC. Methods This prospective, nonrandomized study involved 55 patients with SAC and 10 age‐ and sex‐matched healthy controls. Serum and tears were collected before and after treatment to analyze the total IgE. SAC patients received the same topical anti‐allergy treatment and were followed‐up every 2 weeks for 1 month. The relationship of tear and serum total IgE concentrations with pollen concentrations and symptom severity before and after treatment was assessed. Results The total IgE concentration in tears was higher in SAC patients than in healthy participants with significant correlations between tear and serum total IgE concentrations. The total IgE concentration in tears, but not in serum, correlated with the pollen concentration and severity of ocular symptoms and reactions in SAC. Treatment‐associated improvements in symptoms and reactions in SAC correlated with decreased concentrations of the tear total IgE. Patients with disease recurrence following treatment demonstrated significantly higher tear total IgE concentrations than patients with no recurrence. Conclusion The total tear IgE level can indicate the severity and predict the prognosis of SAC more accurately than the serum total IgE.https://doi.org/10.1002/clt2.12139diagnosisprognosisseasonal allergic conjunctivitistearstotal IgE |
| spellingShingle | Jiayu Bao Lei Tian Yifan Meng Binge Wu Jingyi Wang Jing He Qiyan Shao Chengshuo Wang Ying Jie Luo Zhang Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis Clinical and Translational Allergy diagnosis prognosis seasonal allergic conjunctivitis tears total IgE |
| title | Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis |
| title_full | Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis |
| title_fullStr | Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis |
| title_full_unstemmed | Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis |
| title_short | Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis |
| title_sort | total ige in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis |
| topic | diagnosis prognosis seasonal allergic conjunctivitis tears total IgE |
| url | https://doi.org/10.1002/clt2.12139 |
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