Quantitative Structure-Activity Relationship, Structure-based Design, and ADMET studies of pyrimethamine and cycloguanil analogs inhibitors of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS).

Quantitative Structure-Activity Relationship, Structure-based Design, and ADMET studies of pyrimethamine and cycloguanil analogs inhibitors of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS).

ABSTRACT: The increasing resistance of the malarial parasite to readily available drugs ensures a continuous battle against endemic diseases. Hence, the search for antimalarial drugs with enhanced activity against the P. falciparum strain becomes an endless one. The objective of this study is to use...

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Bibliographic Details
Main Authors: Zakari Ya'u Ibrahim, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen Eyije Abechi, Sulaiman Isyaku
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Chemical Physics Impact
Subjects:
Qsar
Design
Docking
Pyrimethamine
Cycloguanil
Admet
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022422000706

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