Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane Anaesthesia
Introduction: Emergence agitation (EA) and emergence delirium (ED) are common in paediatric patients after general anaesthesia with Sevoflurane. The present study aimed at comparing EA and ED in paediatric patients receiving either Dexmedetomidine or Midazolam pre-medication. Methodology: The presen...
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| Format: | Article |
| Language: | English |
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Sonali Sharma on behalf of Rajasthan University of Health Sciences
2024-03-01
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| Series: | RUHS Journal of Health Sciences |
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| Online Access: | https://ruhsjhs.in/articleDetails.php?artid=TWpjMw== |
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| author | Raghavendra Prasad Saya, Sonu Sesham, Arunalatha Paigeri Sappagu, Kailashnath Reddy, Chenna Reddy , Sunil Chiruvella |
| author_facet | Raghavendra Prasad Saya, Sonu Sesham, Arunalatha Paigeri Sappagu, Kailashnath Reddy, Chenna Reddy , Sunil Chiruvella |
| author_sort | Raghavendra Prasad Saya, Sonu Sesham, Arunalatha Paigeri Sappagu, Kailashnath Reddy, Chenna Reddy , Sunil Chiruvella |
| collection | DOAJ |
| description | Introduction: Emergence agitation (EA) and emergence delirium (ED) are common in paediatric patients after general anaesthesia with Sevoflurane. The present study aimed at comparing EA and ED in paediatric patients receiving either Dexmedetomidine or Midazolam pre-medication. Methodology: The present prospective randomized double blind study was carried out in a teaching hospital. A total of 180 paediatric patients aged between 2-12 years undergoing surgery under general anaesthesia with Sevoflurane were enrolled. Patients were divided into two groups, group A received oral Midazolam 0.5 mg/kg 45 minutes before induction and group B received oral Dexmedetomidine 4 mcg/kg 45 minutes before induction of anaesthesia. Vital parameters, incidence and severity of EA, and duration of stay in post anaesthesia care unit were recorded. Results: Mean arterial pressure (MAP) and heart rate (HR) were significantly less in group B. Incidence of EA was 35.5% in group A and 2.22% in group B (p-value≤ 0.0001). Severity of agitation was significantly less in group B (p value ≤ 0.0001). Conclusion: Oral Dexmedetomidine premedication provides better recovery and reduces the incidence and severity of EA in paediatric patients after Sevoflurane anaesthesia in comparison to oral Midazolam. |
| first_indexed | 2024-04-24T16:10:46Z |
| format | Article |
| id | doaj.art-2a007262b9cb41a886c8afdbab20ef58 |
| institution | Directory Open Access Journal |
| issn | 2456-8309 2582-3590 |
| language | English |
| last_indexed | 2024-04-24T16:10:46Z |
| publishDate | 2024-03-01 |
| publisher | Sonali Sharma on behalf of Rajasthan University of Health Sciences |
| record_format | Article |
| series | RUHS Journal of Health Sciences |
| spelling | doaj.art-2a007262b9cb41a886c8afdbab20ef582024-03-31T18:20:35ZengSonali Sharma on behalf of Rajasthan University of Health SciencesRUHS Journal of Health Sciences2456-83092582-35902024-03-01http://dx.doi.org/10.37821/ruhsjhs.9.1.2024.661Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane AnaesthesiaRaghavendra Prasad Saya, Sonu Sesham, Arunalatha Paigeri Sappagu, Kailashnath Reddy, Chenna Reddy , Sunil Chiruvella0Associate Professor, Assistant Professor, Professor, Department of Anaesthesiology, Government Medical College, Kadapa; Associate Professor, Department of Anaesthesiology, Government Medical College, Anantapur; ExProfessor and Head, Department of Anaesthesiology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.Introduction: Emergence agitation (EA) and emergence delirium (ED) are common in paediatric patients after general anaesthesia with Sevoflurane. The present study aimed at comparing EA and ED in paediatric patients receiving either Dexmedetomidine or Midazolam pre-medication. Methodology: The present prospective randomized double blind study was carried out in a teaching hospital. A total of 180 paediatric patients aged between 2-12 years undergoing surgery under general anaesthesia with Sevoflurane were enrolled. Patients were divided into two groups, group A received oral Midazolam 0.5 mg/kg 45 minutes before induction and group B received oral Dexmedetomidine 4 mcg/kg 45 minutes before induction of anaesthesia. Vital parameters, incidence and severity of EA, and duration of stay in post anaesthesia care unit were recorded. Results: Mean arterial pressure (MAP) and heart rate (HR) were significantly less in group B. Incidence of EA was 35.5% in group A and 2.22% in group B (p-value≤ 0.0001). Severity of agitation was significantly less in group B (p value ≤ 0.0001). Conclusion: Oral Dexmedetomidine premedication provides better recovery and reduces the incidence and severity of EA in paediatric patients after Sevoflurane anaesthesia in comparison to oral Midazolam.https://ruhsjhs.in/articleDetails.php?artid=TWpjMw==Dexmedetomidine, Emergence agitation, Mida zolam, Sevoflurane. |
| spellingShingle | Raghavendra Prasad Saya, Sonu Sesham, Arunalatha Paigeri Sappagu, Kailashnath Reddy, Chenna Reddy , Sunil Chiruvella Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane Anaesthesia RUHS Journal of Health Sciences Dexmedetomidine, Emergence agitation, Mida zolam, Sevoflurane. |
| title | Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane Anaesthesia |
| title_full | Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane Anaesthesia |
| title_fullStr | Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane Anaesthesia |
| title_full_unstemmed | Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane Anaesthesia |
| title_short | Comparative Study of Oral Dexmedetomidine and Oral Midazolam on Postoperative Recovery Characteristics of Paediatric Patients after Sevoflurane Anaesthesia |
| title_sort | comparative study of oral dexmedetomidine and oral midazolam on postoperative recovery characteristics of paediatric patients after sevoflurane anaesthesia |
| topic | Dexmedetomidine, Emergence agitation, Mida zolam, Sevoflurane. |
| url | https://ruhsjhs.in/articleDetails.php?artid=TWpjMw== |
| work_keys_str_mv | AT raghavendraprasadsayasonuseshamarunalathapaigerisappagukailashnathreddychennareddysunilchiruvella comparativestudyoforaldexmedetomidineandoralmidazolamonpostoperativerecoverycharacteristicsofpaediatricpatientsaftersevofluraneanaesthesia |