Pituitary Gland Functional Connectivity and BMI
The pituitary gland (PG) influences body weight through hormonal releases; however, the relation between body weight and PG’s co-activities with other brain regions remains unclear. Here, we aimed to identify (1) the functional connectivity of the PG and (2) PG functional connectivity associated wit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00120/full |
| _version_ | 1818911882298261504 |
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| author | Paige Rucker Toshikazu Ikuta |
| author_facet | Paige Rucker Toshikazu Ikuta |
| author_sort | Paige Rucker |
| collection | DOAJ |
| description | The pituitary gland (PG) influences body weight through hormonal releases; however, the relation between body weight and PG’s co-activities with other brain regions remains unclear. Here, we aimed to identify (1) the functional connectivity of the PG and (2) PG functional connectivity associated with body mass index by examining resting state functional magnetic resonance imaging data. Using enhanced Nathan Kline Institute-Rockland Sample, PG functional connectivity of 494 individuals was analyzed to assess in voxel-wise fashion. A negative association was found between BMI and PG functional connectivity with the orbitofrontal cortex, hippocampus, putamen, and temporal lobe. Our results show PG dysconnectivity to these regions is associated with higher BMI and implicate that the connectivity between these dopaminergic regions and PG may be associated with body weight maintenance through feeding behavior and growth. |
| first_indexed | 2024-12-19T23:05:45Z |
| format | Article |
| id | doaj.art-2a00943e206844779db6ebdfb7595287 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T23:05:45Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2a00943e206844779db6ebdfb75952872022-12-21T20:02:23ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-03-011310.3389/fnins.2019.00120418380Pituitary Gland Functional Connectivity and BMIPaige Rucker0Toshikazu Ikuta1School of Medicine, The University of Mississippi Medical Center, Jackson, MS, United StatesDepartment of Communication Sciences and Disorders, The University of Mississippi, Oxford, MS, United StatesThe pituitary gland (PG) influences body weight through hormonal releases; however, the relation between body weight and PG’s co-activities with other brain regions remains unclear. Here, we aimed to identify (1) the functional connectivity of the PG and (2) PG functional connectivity associated with body mass index by examining resting state functional magnetic resonance imaging data. Using enhanced Nathan Kline Institute-Rockland Sample, PG functional connectivity of 494 individuals was analyzed to assess in voxel-wise fashion. A negative association was found between BMI and PG functional connectivity with the orbitofrontal cortex, hippocampus, putamen, and temporal lobe. Our results show PG dysconnectivity to these regions is associated with higher BMI and implicate that the connectivity between these dopaminergic regions and PG may be associated with body weight maintenance through feeding behavior and growth.https://www.frontiersin.org/article/10.3389/fnins.2019.00120/fullpituitary glandfunctional connectivityresting state fMRIgustatory cortexcaudate head |
| spellingShingle | Paige Rucker Toshikazu Ikuta Pituitary Gland Functional Connectivity and BMI Frontiers in Neuroscience pituitary gland functional connectivity resting state fMRI gustatory cortex caudate head |
| title | Pituitary Gland Functional Connectivity and BMI |
| title_full | Pituitary Gland Functional Connectivity and BMI |
| title_fullStr | Pituitary Gland Functional Connectivity and BMI |
| title_full_unstemmed | Pituitary Gland Functional Connectivity and BMI |
| title_short | Pituitary Gland Functional Connectivity and BMI |
| title_sort | pituitary gland functional connectivity and bmi |
| topic | pituitary gland functional connectivity resting state fMRI gustatory cortex caudate head |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00120/full |
| work_keys_str_mv | AT paigerucker pituitaryglandfunctionalconnectivityandbmi AT toshikazuikuta pituitaryglandfunctionalconnectivityandbmi |