Exploring the Causal Effect of Constipation on Parkinson’s Disease Through Mediation Analysis of Microbial Data

Exploring the Causal Effect of Constipation on Parkinson’s Disease Through Mediation Analysis of Microbial Data

Background and AimsParkinson’s disease (PD) is a worldwide neurodegenerative disease with an increasing global burden, while constipation is an important risk factor for PD. The gastrointestinal tract had been proposed as the origin of PD in Braak’s gut–brain axis hypothesis, and there is increasing...

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Bibliographic Details
Main Authors: Shih-Chen Fu, Ling-Chieh Shih, Pei-Hua Wu, Yi-Chen Hsieh, Chung-Han Lee, Sheng-Hsuan Lin, Hsiuying Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Parkinson’s disease
constipation
microbiome
intestinal microbial changes
mediation analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.871710/full

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