Resilience of a FIT screening programme against screening fatigue: a modelling study
Abstract Background Repeated participation is important in faecal immunochemical testing (FIT) screening for colorectal cancer (CRC). However, a large number of screening invitations over time may lead to screening fatigue and consequently, decreased participation rates. We evaluated the impact of s...
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| Format: | Article |
| Language: | English |
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BMC
2016-09-01
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| Series: | BMC Public Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12889-016-3667-8 |
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| author | Marjolein J. E. Greuter Johannes Berkhof Karen Canfell Jie-Bin Lew Evelien Dekker Veerle M. H. Coupé |
| author_facet | Marjolein J. E. Greuter Johannes Berkhof Karen Canfell Jie-Bin Lew Evelien Dekker Veerle M. H. Coupé |
| author_sort | Marjolein J. E. Greuter |
| collection | DOAJ |
| description | Abstract Background Repeated participation is important in faecal immunochemical testing (FIT) screening for colorectal cancer (CRC). However, a large number of screening invitations over time may lead to screening fatigue and consequently, decreased participation rates. We evaluated the impact of screening fatigue on overall screening programme effectiveness. Methods Using the ASCCA model, we simulated the Dutch CRC screening programme consisting of biennial FIT screening in individuals aged 55–75. We studied the resilience of the programme against heterogeneity in screening attendance and decrease in participation rate due to screening fatigue. Outcomes were reductions in CRC incidence and mortality compared to no screening. Results Assuming a homogenous 63 % participation, i.e., each round each individual was equally likely to attend screening, 30 years of screening reduced CRC incidence and mortality by 39 and 53 %, respectively, compared to no screening. When assuming clustered participation, i.e., three subgroups of individuals with a high (95 %), moderate (65 %) and low (5 %) participation rate, screening was less effective; reductions were 33 % for CRC incidence and 43 % for CRC mortality. Screening fatigue considerably reduced screening effectiveness; if individuals refrained from screening after three negative screens, model-predicted incidence reductions decreased to 25 and 18 % under homogenous and clustered participation, respectively. Figures were 34 and 25 % for mortality reduction. Conclusions Screening will substantially decrease CRC incidence and mortality. However, screening effectiveness can be seriously compromised if screening fatigue occurs. This warrants careful monitoring of individual screening behaviour and consideration of targeted invitation systems in individuals who have (repeatedly) missed screening rounds. |
| first_indexed | 2024-12-23T11:55:33Z |
| format | Article |
| id | doaj.art-2a06090afa93410eb8f52bdf36833214 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-23T11:55:33Z |
| publishDate | 2016-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-2a06090afa93410eb8f52bdf368332142022-12-21T17:48:05ZengBMCBMC Public Health1471-24582016-09-011611810.1186/s12889-016-3667-8Resilience of a FIT screening programme against screening fatigue: a modelling studyMarjolein J. E. Greuter0Johannes Berkhof1Karen Canfell2Jie-Bin Lew3Evelien Dekker4Veerle M. H. Coupé5Department of Epidemiology and Biostatistics, VU University Medical CenterDepartment of Epidemiology and Biostatistics, VU University Medical CenterCancer Research Division, Cancer Council NSWCancer Research Division, Cancer Council NSWDepartment of Gastroenterology and Hepatology, Academic Medical CentreDepartment of Epidemiology and Biostatistics, VU University Medical CenterAbstract Background Repeated participation is important in faecal immunochemical testing (FIT) screening for colorectal cancer (CRC). However, a large number of screening invitations over time may lead to screening fatigue and consequently, decreased participation rates. We evaluated the impact of screening fatigue on overall screening programme effectiveness. Methods Using the ASCCA model, we simulated the Dutch CRC screening programme consisting of biennial FIT screening in individuals aged 55–75. We studied the resilience of the programme against heterogeneity in screening attendance and decrease in participation rate due to screening fatigue. Outcomes were reductions in CRC incidence and mortality compared to no screening. Results Assuming a homogenous 63 % participation, i.e., each round each individual was equally likely to attend screening, 30 years of screening reduced CRC incidence and mortality by 39 and 53 %, respectively, compared to no screening. When assuming clustered participation, i.e., three subgroups of individuals with a high (95 %), moderate (65 %) and low (5 %) participation rate, screening was less effective; reductions were 33 % for CRC incidence and 43 % for CRC mortality. Screening fatigue considerably reduced screening effectiveness; if individuals refrained from screening after three negative screens, model-predicted incidence reductions decreased to 25 and 18 % under homogenous and clustered participation, respectively. Figures were 34 and 25 % for mortality reduction. Conclusions Screening will substantially decrease CRC incidence and mortality. However, screening effectiveness can be seriously compromised if screening fatigue occurs. This warrants careful monitoring of individual screening behaviour and consideration of targeted invitation systems in individuals who have (repeatedly) missed screening rounds.http://link.springer.com/article/10.1186/s12889-016-3667-8Colorectal cancerScreeningParticipation |
| spellingShingle | Marjolein J. E. Greuter Johannes Berkhof Karen Canfell Jie-Bin Lew Evelien Dekker Veerle M. H. Coupé Resilience of a FIT screening programme against screening fatigue: a modelling study BMC Public Health Colorectal cancer Screening Participation |
| title | Resilience of a FIT screening programme against screening fatigue: a modelling study |
| title_full | Resilience of a FIT screening programme against screening fatigue: a modelling study |
| title_fullStr | Resilience of a FIT screening programme against screening fatigue: a modelling study |
| title_full_unstemmed | Resilience of a FIT screening programme against screening fatigue: a modelling study |
| title_short | Resilience of a FIT screening programme against screening fatigue: a modelling study |
| title_sort | resilience of a fit screening programme against screening fatigue a modelling study |
| topic | Colorectal cancer Screening Participation |
| url | http://link.springer.com/article/10.1186/s12889-016-3667-8 |
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