Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease

Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease

Summary It is indispensable to thoroughly characterize each animal model in order to distinguish between primary and secondary effects of genetic changes. The present study analyzed Nod1 and Nod2 double deficient (Nod1/2 DKO) mice under physiological and inflammatory conditions. Nod1 and Nod2 are me...

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Bibliographic Details
Main Authors: Ingrid Stroo, Loes M. Butter, Nike Claessen, Gwen J. Teske, Stephen J. Rubino, Stephen E. Girardin, Sandrine Florquin, Jaklien C. Leemans
Format: Article
Language:English
Published: The Company of Biologists 2012-10-01
Series:Biology Open
Subjects:
Innate immune receptors
Kidney
Knockout mouse
Phenotype
Systemic inflammation
Online Access:http://bio.biologists.org/content/1/12/1239

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