Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus
Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for humans, wherein it is responsible for a large variety of clinical forms ranging from allergic diseases to life-threatening disseminated infections. The contamination occurs by inhalation of conidia present in the...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01041/full |
| _version_ | 1818907450761281536 |
|---|---|
| author | Jeanne Bigot Loïc Guillot Juliette Guitard Manon Ruffin Harriet Corvol Viviane Balloy Christophe Hennequin |
| author_facet | Jeanne Bigot Loïc Guillot Juliette Guitard Manon Ruffin Harriet Corvol Viviane Balloy Christophe Hennequin |
| author_sort | Jeanne Bigot |
| collection | DOAJ |
| description | Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for humans, wherein it is responsible for a large variety of clinical forms ranging from allergic diseases to life-threatening disseminated infections. The contamination occurs by inhalation of conidia present in the air, and the first encounter of this fungus in the human host is most likely with the bronchial epithelial cells. Although alveolar macrophages have been widely studied in the Aspergillus–lung interaction, increasing evidence suggests that bronchial epithelium plays a key role in responding to the fungus. This review focuses on the innate immune response of the bronchial epithelial cells against A. fumigatus, the predominant pathogenic species. We have also detailed the molecular interactants and the effects of the different modes of interaction between these cells and the fungus. |
| first_indexed | 2024-12-19T21:55:19Z |
| format | Article |
| id | doaj.art-2a0a97af7ec34106a427a2d9f35c3861 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T21:55:19Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2a0a97af7ec34106a427a2d9f35c38612022-12-21T20:04:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.01041537755Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatusJeanne Bigot0Loïc Guillot1Juliette Guitard2Manon Ruffin3Harriet Corvol4Viviane Balloy5Christophe Hennequin6Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Paris, FranceSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, FranceSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Paris, FranceSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, FranceSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Trousseau, Service de Pneumologie Pédiatrique, Paris, FranceSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, FranceSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Paris, FranceAspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for humans, wherein it is responsible for a large variety of clinical forms ranging from allergic diseases to life-threatening disseminated infections. The contamination occurs by inhalation of conidia present in the air, and the first encounter of this fungus in the human host is most likely with the bronchial epithelial cells. Although alveolar macrophages have been widely studied in the Aspergillus–lung interaction, increasing evidence suggests that bronchial epithelium plays a key role in responding to the fungus. This review focuses on the innate immune response of the bronchial epithelial cells against A. fumigatus, the predominant pathogenic species. We have also detailed the molecular interactants and the effects of the different modes of interaction between these cells and the fungus.https://www.frontiersin.org/article/10.3389/fimmu.2020.01041/fullbronchial epithelial cellsAspergillus fumigatusinnate immunitylung infectionmucociliary machinery |
| spellingShingle | Jeanne Bigot Loïc Guillot Juliette Guitard Manon Ruffin Harriet Corvol Viviane Balloy Christophe Hennequin Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus Frontiers in Immunology bronchial epithelial cells Aspergillus fumigatus innate immunity lung infection mucociliary machinery |
| title | Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus |
| title_full | Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus |
| title_fullStr | Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus |
| title_full_unstemmed | Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus |
| title_short | Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus |
| title_sort | bronchial epithelial cells on the front line to fight lung infection causing aspergillus fumigatus |
| topic | bronchial epithelial cells Aspergillus fumigatus innate immunity lung infection mucociliary machinery |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01041/full |
| work_keys_str_mv | AT jeannebigot bronchialepithelialcellsonthefrontlinetofightlunginfectioncausingaspergillusfumigatus AT loicguillot bronchialepithelialcellsonthefrontlinetofightlunginfectioncausingaspergillusfumigatus AT julietteguitard bronchialepithelialcellsonthefrontlinetofightlunginfectioncausingaspergillusfumigatus AT manonruffin bronchialepithelialcellsonthefrontlinetofightlunginfectioncausingaspergillusfumigatus AT harrietcorvol bronchialepithelialcellsonthefrontlinetofightlunginfectioncausingaspergillusfumigatus AT vivianeballoy bronchialepithelialcellsonthefrontlinetofightlunginfectioncausingaspergillusfumigatus AT christophehennequin bronchialepithelialcellsonthefrontlinetofightlunginfectioncausingaspergillusfumigatus |