What the BTBR/J mouse has taught us about diabetes and diabetic complications

What the BTBR/J mouse has taught us about diabetes and diabetic complications

Summary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could s...

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Bibliographic Details
Main Authors: Mark P. Keller, Kelly L. Hudkins, Anath Shalev, Sushant Bhatnagar, Melkam A. Kebede, Matthew J. Merrins, Dawn Belt Davis, Charles E. Alpers, Michelle E. Kimple, Alan D. Attie
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Animal physiology
Human metabolism
Model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223011136
Description
Summary:Summary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model.
ISSN:2589-0042

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