What the BTBR/J mouse has taught us about diabetes and diabetic complications
Summary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could s...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223011136 |
| _version_ | 1797774535238352896 |
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| author | Mark P. Keller Kelly L. Hudkins Anath Shalev Sushant Bhatnagar Melkam A. Kebede Matthew J. Merrins Dawn Belt Davis Charles E. Alpers Michelle E. Kimple Alan D. Attie |
| author_facet | Mark P. Keller Kelly L. Hudkins Anath Shalev Sushant Bhatnagar Melkam A. Kebede Matthew J. Merrins Dawn Belt Davis Charles E. Alpers Michelle E. Kimple Alan D. Attie |
| author_sort | Mark P. Keller |
| collection | DOAJ |
| description | Summary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model. |
| first_indexed | 2024-03-12T22:22:29Z |
| format | Article |
| id | doaj.art-2a0d513bf5f14082a8f6d638bd1a6e49 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:22:29Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-2a0d513bf5f14082a8f6d638bd1a6e492023-07-23T04:55:16ZengElsevieriScience2589-00422023-07-01267107036What the BTBR/J mouse has taught us about diabetes and diabetic complicationsMark P. Keller0Kelly L. Hudkins1Anath Shalev2Sushant Bhatnagar3Melkam A. Kebede4Matthew J. Merrins5Dawn Belt Davis6Charles E. Alpers7Michelle E. Kimple8Alan D. Attie9Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USADepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UKDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UKSchool of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Camperdown, Sydney, NSW 2006, AustraliaDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USADepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USADepartment of Pathology, University of Washington Medical Center, Seattle, WA 98195, USADepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USADepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Corresponding authorSummary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model.http://www.sciencedirect.com/science/article/pii/S2589004223011136Animal physiologyHuman metabolismModel organism |
| spellingShingle | Mark P. Keller Kelly L. Hudkins Anath Shalev Sushant Bhatnagar Melkam A. Kebede Matthew J. Merrins Dawn Belt Davis Charles E. Alpers Michelle E. Kimple Alan D. Attie What the BTBR/J mouse has taught us about diabetes and diabetic complications iScience Animal physiology Human metabolism Model organism |
| title | What the BTBR/J mouse has taught us about diabetes and diabetic complications |
| title_full | What the BTBR/J mouse has taught us about diabetes and diabetic complications |
| title_fullStr | What the BTBR/J mouse has taught us about diabetes and diabetic complications |
| title_full_unstemmed | What the BTBR/J mouse has taught us about diabetes and diabetic complications |
| title_short | What the BTBR/J mouse has taught us about diabetes and diabetic complications |
| title_sort | what the btbr j mouse has taught us about diabetes and diabetic complications |
| topic | Animal physiology Human metabolism Model organism |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223011136 |
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