Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer?
Objective: The aim of the study was to evaluate which apparent diffusion coefficient (ADC) parameter can predict the aggressiveness of prostate cancer in patients confirmed by radical prostatectomy specimens. Materials and Methods: Patients who underwent radical prostatectomy for prostate cancer bet...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-12-01
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| Series: | Journal of Urological Surgery |
| Subjects: | |
| Online Access: |
http://jurolsurgery.org/archives/archive-detail/article-preview/apparent-diffusion-coefficient-of-variation-adcsub/62782
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| _version_ | 1797390193599184896 |
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| author | Aylin Altan Kuş Burak Çıtamak Ali Tekin |
| author_facet | Aylin Altan Kuş Burak Çıtamak Ali Tekin |
| author_sort | Aylin Altan Kuş |
| collection | DOAJ |
| description | Objective: The aim of the study was to evaluate which apparent diffusion coefficient (ADC) parameter can predict the aggressiveness of prostate cancer in patients confirmed by radical prostatectomy specimens. Materials and Methods: Patients who underwent radical prostatectomy for prostate cancer between October 2019 and June 2023 were retrospectively reviewed. Patients were separated into two groups based on the International Society of Urological Pathology (ISUP) classification, and the correlation between ADC metrics and ADC parameters, including ADCmean, ADCcoefficient of variation (ADCcv), and ISUP classification the aggressiveness of prostate cancer was studied. Results: Fifty-seven patients were included in the study. Patients were evaluated as low-risk (group 1) (n=40), and high-risk (group) (n=17). ADCmean values for the two groups were not significantly different (p=0.218). ADCcv values that can demonstrate tumour heterogeneity index were higher in group 2 than in group 1 (p<0.001). Multivariate analysis revealed that extracapsular extension, positive surgical margin, and ADCcv values indicated tumour proliferation, whereas seminal vesicle invasion, prostate-specific antigen levels, and body mass index were not correlated with ISUP grade groups. Conclusion: ADCcv is a promising new biomarker for tumour aggressiveness in prostate cancer. |
| first_indexed | 2024-03-08T23:08:15Z |
| format | Article |
| id | doaj.art-2a0dc7eed3574d41930c959bddb27a28 |
| institution | Directory Open Access Journal |
| issn | 2148-9580 |
| language | English |
| last_indexed | 2024-03-08T23:08:15Z |
| publishDate | 2023-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Urological Surgery |
| spelling | doaj.art-2a0dc7eed3574d41930c959bddb27a282023-12-15T10:16:31ZengGalenos YayineviJournal of Urological Surgery2148-95802023-12-0110429530010.4274/jus.galenos.2023.2023-8-513049054Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer?Aylin Altan Kuş0Burak Çıtamak1Ali Tekin2 Acıbadem University Atakent Hospital, Department of Radiology, İstanbul, Turkiye Acıbadem University Atakent Hospital, Department of Urology, İstanbul, Turkiye Acıbadem University Atakent Hospital, Department of Urology, İstanbul, Turkiye Objective: The aim of the study was to evaluate which apparent diffusion coefficient (ADC) parameter can predict the aggressiveness of prostate cancer in patients confirmed by radical prostatectomy specimens. Materials and Methods: Patients who underwent radical prostatectomy for prostate cancer between October 2019 and June 2023 were retrospectively reviewed. Patients were separated into two groups based on the International Society of Urological Pathology (ISUP) classification, and the correlation between ADC metrics and ADC parameters, including ADCmean, ADCcoefficient of variation (ADCcv), and ISUP classification the aggressiveness of prostate cancer was studied. Results: Fifty-seven patients were included in the study. Patients were evaluated as low-risk (group 1) (n=40), and high-risk (group) (n=17). ADCmean values for the two groups were not significantly different (p=0.218). ADCcv values that can demonstrate tumour heterogeneity index were higher in group 2 than in group 1 (p<0.001). Multivariate analysis revealed that extracapsular extension, positive surgical margin, and ADCcv values indicated tumour proliferation, whereas seminal vesicle invasion, prostate-specific antigen levels, and body mass index were not correlated with ISUP grade groups. Conclusion: ADCcv is a promising new biomarker for tumour aggressiveness in prostate cancer. http://jurolsurgery.org/archives/archive-detail/article-preview/apparent-diffusion-coefficient-of-variation-adcsub/62782 diffusion weighted imagingapparent diffusion coefficientisup grade groupprostate cancerprostatectomy |
| spellingShingle | Aylin Altan Kuş Burak Çıtamak Ali Tekin Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer? Journal of Urological Surgery diffusion weighted imaging apparent diffusion coefficient isup grade group prostate cancer prostatectomy |
| title | Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer? |
| title_full | Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer? |
| title_fullStr | Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer? |
| title_full_unstemmed | Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer? |
| title_short | Apparent Diffusion Coefficient of Variation (ADCcv): A New Biomarker for Aggressiveness in Prostate Cancer? |
| title_sort | apparent diffusion coefficient of variation adccv a new biomarker for aggressiveness in prostate cancer |
| topic | diffusion weighted imaging apparent diffusion coefficient isup grade group prostate cancer prostatectomy |
| url |
http://jurolsurgery.org/archives/archive-detail/article-preview/apparent-diffusion-coefficient-of-variation-adcsub/62782
|
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