Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit
Abstract Background Ventilator-associated pneumonia (VAP) is a severe infection among patients in the neurosurgery intensive care unit (NICU). Methods We retrospectively evaluated risk factors for early-onset ventilator-associated pneumonia (EOVAP) from January 2019 to December 2019 at a NICU. A tot...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-01-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07053-7 |
| _version_ | 1819261431217913856 |
|---|---|
| author | Guojie Teng Ning Wang Xiuhong Nie Lin Zhang Hongjun Liu |
| author_facet | Guojie Teng Ning Wang Xiuhong Nie Lin Zhang Hongjun Liu |
| author_sort | Guojie Teng |
| collection | DOAJ |
| description | Abstract Background Ventilator-associated pneumonia (VAP) is a severe infection among patients in the neurosurgery intensive care unit (NICU). Methods We retrospectively evaluated risk factors for early-onset ventilator-associated pneumonia (EOVAP) from January 2019 to December 2019 at a NICU. A total of 89 NICU patients who were intubated within 48 h of onset and whose mechanical ventilation time was at least 7 days were enrolled. We evaluated EOVAP that occurred within the first 7 days after the onset of mechanical ventilation. The enrolled patients had no history of chronic lung disease and no clinical manifestations of infection before intubation. Clinical data of patients were recorded, and the incidence of and risk factors for EOVAP were analyzed. Patients were also grouped by age (≥ 65 vs. < 65 years) and whether they had received hypothermia treatment or not. Results Among 89 mechanically ventilated patients (49 men and 40 women; the mean age ± SD was 60.1 ± 14.3 years), 40 patients (44.9%) developed EOVAP within 7 days and 14 patients (15.7%) had a multidrug resistant bacterial infection. Binary logistic regression analysis indicated that older age (≥ 65 years) (odds ratio [OR]:3.53, 95% confidence interval [CI]:1.27–9.79, P = 0.015) and therapeutic hypothermia (OR:3.68, CI:1.10–12.31, p = 0.034) were independent predictors of EOVAP. Levels of peripheral blood leukocytes, neutrophils and platelets were lower in the therapeutic hypothermia group than those who did not receive hypothermia treatment. Conclusions This study found that older age (≥ 65 years) and therapeutic hypothermia were independently associated with the risk of EOVAP in NICU patients. |
| first_indexed | 2024-12-23T19:41:41Z |
| format | Article |
| id | doaj.art-2a11319ad7fb4b21b3ae7734cb0b7fbb |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-23T19:41:41Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-2a11319ad7fb4b21b3ae7734cb0b7fbb2022-12-21T17:33:38ZengBMCBMC Infectious Diseases1471-23342022-01-012211810.1186/s12879-022-07053-7Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unitGuojie Teng0Ning Wang1Xiuhong Nie2Lin Zhang3Hongjun Liu4Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital Capital Medical UniversityDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, China International Neuroscience Institute (China-INI)Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital Capital Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Xuanwu Hospital Capital Medical UniversityDepartment of Evidence-Based Medicine, Xuanwu Hospital Capital Medical UniversityAbstract Background Ventilator-associated pneumonia (VAP) is a severe infection among patients in the neurosurgery intensive care unit (NICU). Methods We retrospectively evaluated risk factors for early-onset ventilator-associated pneumonia (EOVAP) from January 2019 to December 2019 at a NICU. A total of 89 NICU patients who were intubated within 48 h of onset and whose mechanical ventilation time was at least 7 days were enrolled. We evaluated EOVAP that occurred within the first 7 days after the onset of mechanical ventilation. The enrolled patients had no history of chronic lung disease and no clinical manifestations of infection before intubation. Clinical data of patients were recorded, and the incidence of and risk factors for EOVAP were analyzed. Patients were also grouped by age (≥ 65 vs. < 65 years) and whether they had received hypothermia treatment or not. Results Among 89 mechanically ventilated patients (49 men and 40 women; the mean age ± SD was 60.1 ± 14.3 years), 40 patients (44.9%) developed EOVAP within 7 days and 14 patients (15.7%) had a multidrug resistant bacterial infection. Binary logistic regression analysis indicated that older age (≥ 65 years) (odds ratio [OR]:3.53, 95% confidence interval [CI]:1.27–9.79, P = 0.015) and therapeutic hypothermia (OR:3.68, CI:1.10–12.31, p = 0.034) were independent predictors of EOVAP. Levels of peripheral blood leukocytes, neutrophils and platelets were lower in the therapeutic hypothermia group than those who did not receive hypothermia treatment. Conclusions This study found that older age (≥ 65 years) and therapeutic hypothermia were independently associated with the risk of EOVAP in NICU patients.https://doi.org/10.1186/s12879-022-07053-7Early-onset ventilator-associated pneumoniaRisk factorsAgingHypothermia therapyNeurosurgical intensive care unit |
| spellingShingle | Guojie Teng Ning Wang Xiuhong Nie Lin Zhang Hongjun Liu Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit BMC Infectious Diseases Early-onset ventilator-associated pneumonia Risk factors Aging Hypothermia therapy Neurosurgical intensive care unit |
| title | Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit |
| title_full | Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit |
| title_fullStr | Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit |
| title_full_unstemmed | Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit |
| title_short | Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit |
| title_sort | analysis of risk factors for early onset ventilator associated pneumonia in a neurosurgical intensive care unit |
| topic | Early-onset ventilator-associated pneumonia Risk factors Aging Hypothermia therapy Neurosurgical intensive care unit |
| url | https://doi.org/10.1186/s12879-022-07053-7 |
| work_keys_str_mv | AT guojieteng analysisofriskfactorsforearlyonsetventilatorassociatedpneumoniainaneurosurgicalintensivecareunit AT ningwang analysisofriskfactorsforearlyonsetventilatorassociatedpneumoniainaneurosurgicalintensivecareunit AT xiuhongnie analysisofriskfactorsforearlyonsetventilatorassociatedpneumoniainaneurosurgicalintensivecareunit AT linzhang analysisofriskfactorsforearlyonsetventilatorassociatedpneumoniainaneurosurgicalintensivecareunit AT hongjunliu analysisofriskfactorsforearlyonsetventilatorassociatedpneumoniainaneurosurgicalintensivecareunit |