The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study
Previous studies indicated that laser acupuncture (LA) may effectively treat various medical conditions. However, brain responses associated with LA intervention have not been fully investigated. This study is focused on the effect of LA with different energy density (ED) in brain using resting-stat...
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1264217/full |
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| author | Yi-Chuan Chang Yi-Chuan Chang Chun-Ming Chen Ing-Shiow Lay Ing-Shiow Lay Yu-Chen Lee Yu-Chen Lee Yu-Chen Lee Cheng-Hao Tu |
| author_facet | Yi-Chuan Chang Yi-Chuan Chang Chun-Ming Chen Ing-Shiow Lay Ing-Shiow Lay Yu-Chen Lee Yu-Chen Lee Yu-Chen Lee Cheng-Hao Tu |
| author_sort | Yi-Chuan Chang |
| collection | DOAJ |
| description | Previous studies indicated that laser acupuncture (LA) may effectively treat various medical conditions. However, brain responses associated with LA intervention have not been fully investigated. This study is focused on the effect of LA with different energy density (ED) in brain using resting-state functional magnetic resonance imaging (fMRI). We hypothesized that different ED would elicit various brain responses. We enrolled healthy adults participants and selected bilateral PC6 (Neiguan) as the intervention points. LA was applied, respectively, with ED of 0, 7.96, or 23.87 J/cm2. Two 500-s resting-state fMRI scans were acquired before and after intervention, respectively. The functional connectivity (FC) was calculated between autonomic nerve system-regulation associated brainstem structures and other brain regions. Compared to other dosages, the FC between rostral ventrolateral medulla and orbitofrontal cortex has more enhanced; the FC between caudal ventrolateral medulla, nucleus of the solitary tract/nucleus ambiguus, and dorsal motor nucleus of the vagus and somatosensory area has more weakened when ED was 23.87 J/cm2. Different dosages of LA have demonstrated varied regions of FC changes between regions of interest and other brain areas, which indicated that variations in EDs might influence the clinical efficacy and subsequent impacts through distinct neural pathways within the brain. |
| first_indexed | 2024-03-11T18:42:26Z |
| format | Article |
| id | doaj.art-2a11476bbc404a35af834fa24f7da333 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-11T18:42:26Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2a11476bbc404a35af834fa24f7da3332023-10-12T09:04:21ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-10-011710.3389/fnins.2023.12642171264217The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI studyYi-Chuan Chang0Yi-Chuan Chang1Chun-Ming Chen2Ing-Shiow Lay3Ing-Shiow Lay4Yu-Chen Lee5Yu-Chen Lee6Yu-Chen Lee7Cheng-Hao Tu8Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, TaiwanDepartment of Chinese Medicine, China Medical University Beigang Hospital, Yunlin, TaiwanDepartment of Medical Imaging, China Medical University Hospital, Taichung, TaiwanDepartment of Chinese Medicine, China Medical University Beigang Hospital, Yunlin, TaiwanSchool of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, TaiwanGraduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, TaiwanSchool of Chinese Medicine, China Medical University, Taichung, TaiwanDepartment of Chinese Medicine, China Medical University Hospital, Taichung, TaiwanGraduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, TaiwanPrevious studies indicated that laser acupuncture (LA) may effectively treat various medical conditions. However, brain responses associated with LA intervention have not been fully investigated. This study is focused on the effect of LA with different energy density (ED) in brain using resting-state functional magnetic resonance imaging (fMRI). We hypothesized that different ED would elicit various brain responses. We enrolled healthy adults participants and selected bilateral PC6 (Neiguan) as the intervention points. LA was applied, respectively, with ED of 0, 7.96, or 23.87 J/cm2. Two 500-s resting-state fMRI scans were acquired before and after intervention, respectively. The functional connectivity (FC) was calculated between autonomic nerve system-regulation associated brainstem structures and other brain regions. Compared to other dosages, the FC between rostral ventrolateral medulla and orbitofrontal cortex has more enhanced; the FC between caudal ventrolateral medulla, nucleus of the solitary tract/nucleus ambiguus, and dorsal motor nucleus of the vagus and somatosensory area has more weakened when ED was 23.87 J/cm2. Different dosages of LA have demonstrated varied regions of FC changes between regions of interest and other brain areas, which indicated that variations in EDs might influence the clinical efficacy and subsequent impacts through distinct neural pathways within the brain.https://www.frontiersin.org/articles/10.3389/fnins.2023.1264217/fulllaser acupunctureNeiguanrostral ventrolateral medullaresting-state functional magnetic resonance imagingfunctional connectivity |
| spellingShingle | Yi-Chuan Chang Yi-Chuan Chang Chun-Ming Chen Ing-Shiow Lay Ing-Shiow Lay Yu-Chen Lee Yu-Chen Lee Yu-Chen Lee Cheng-Hao Tu The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study Frontiers in Neuroscience laser acupuncture Neiguan rostral ventrolateral medulla resting-state functional magnetic resonance imaging functional connectivity |
| title | The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study |
| title_full | The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study |
| title_fullStr | The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study |
| title_full_unstemmed | The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study |
| title_short | The effects of laser acupuncture dosage at PC6 (Neiguan) on brain reactivity: a pilot resting-state fMRI study |
| title_sort | effects of laser acupuncture dosage at pc6 neiguan on brain reactivity a pilot resting state fmri study |
| topic | laser acupuncture Neiguan rostral ventrolateral medulla resting-state functional magnetic resonance imaging functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1264217/full |
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