Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail
Abstract The objectives of the present study was to investigate the effects of resistance training (RT) on serum levels of controlling blood-brain barrier (BBB) permeability indices and cognitive performance in MS women (MS-W). In this randomized control trail study (IRCT registration code: IRCT2012...
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| Format: | Article |
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BMC
2024-03-01
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| Series: | BMC Neuroscience |
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| Online Access: | https://doi.org/10.1186/s12868-024-00856-1 |
| _version_ | 1797275736220893184 |
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| author | Nasrin Niazi Nezhad Abdolhossein Parnow Kianoosh Khamoushian Rasoul Eslami Julien S Baker |
| author_facet | Nasrin Niazi Nezhad Abdolhossein Parnow Kianoosh Khamoushian Rasoul Eslami Julien S Baker |
| author_sort | Nasrin Niazi Nezhad |
| collection | DOAJ |
| description | Abstract The objectives of the present study was to investigate the effects of resistance training (RT) on serum levels of controlling blood-brain barrier (BBB) permeability indices and cognitive performance in MS women (MS-W). In this randomized control trail study (IRCT registration code: IRCT20120912010824N3, 07.09.2023), twenty-five MS-W were randomly divided into sedentary (MS) and resistance exercise (12 weeks/3 times per week/ 60–80% of 1RM) (MS + RT) groups. Fifteen healthy aged-matched women participated as a control group (HCON). The serum level of matrix metalloproteinase-2 (MMP-2), matrix metallopeptidase-9 (MMP-9), tissue metalloproteinase inhibitors-1 (TIMP-1), tissue metalloproteinase inhibitors-2 (TIMP-2), and S100 calcium-binding protein B (S100B) were assessed. In addition, cognitive performance was assessed pre- and post- intervention with the Brief International Cognitive Assessment for MS (BICAMS). A significant reduction in MMP-2, TIMP-2 serum levels, and MMP-2/TIMP-2 ratio were observed in post-test for MS + RT group (p < 0.01) in comparison to the HCON and MS groups; however, no changes were observed in MMP-9, TIMP-1, S100B and MMP-9/TIMP-1 ratio after RT (p > 0.05). The verbal learning was improved in post-test for MS + RT group (p < 0.01), although no change were observed for visuospatial memory and information processing speed (p > 0.05). These findings suggest that resistance training can modify some indices of BBB permeability and improve verbal learning in MS-W. The findings may also be beneficial as a non-pharmacological intervention to reduce inflammation. |
| first_indexed | 2024-03-07T15:17:47Z |
| format | Article |
| id | doaj.art-2a124bb799764126bd10b177ed0696fe |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-03-07T15:17:47Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-2a124bb799764126bd10b177ed0696fe2024-03-05T17:47:50ZengBMCBMC Neuroscience1471-22022024-03-0125111210.1186/s12868-024-00856-1Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trailNasrin Niazi Nezhad0Abdolhossein Parnow1Kianoosh Khamoushian2Rasoul Eslami3Julien S Baker4Sport Bio-Sciences Department, Physical Education and Sports Sciences Faculty, Razi UniversitySport Bio-Sciences Department, Physical Education and Sports Sciences Faculty, Razi UniversityDepartment of Neurology, Kermanshah University of Medical SciencesExercise Physiology Department, Faculty of Physical Education and Sport Sciences, Allameh Tabataba’i UniversityInstitute for Population Health and Medical Informatics, Hong Kong Baptist UniversityAbstract The objectives of the present study was to investigate the effects of resistance training (RT) on serum levels of controlling blood-brain barrier (BBB) permeability indices and cognitive performance in MS women (MS-W). In this randomized control trail study (IRCT registration code: IRCT20120912010824N3, 07.09.2023), twenty-five MS-W were randomly divided into sedentary (MS) and resistance exercise (12 weeks/3 times per week/ 60–80% of 1RM) (MS + RT) groups. Fifteen healthy aged-matched women participated as a control group (HCON). The serum level of matrix metalloproteinase-2 (MMP-2), matrix metallopeptidase-9 (MMP-9), tissue metalloproteinase inhibitors-1 (TIMP-1), tissue metalloproteinase inhibitors-2 (TIMP-2), and S100 calcium-binding protein B (S100B) were assessed. In addition, cognitive performance was assessed pre- and post- intervention with the Brief International Cognitive Assessment for MS (BICAMS). A significant reduction in MMP-2, TIMP-2 serum levels, and MMP-2/TIMP-2 ratio were observed in post-test for MS + RT group (p < 0.01) in comparison to the HCON and MS groups; however, no changes were observed in MMP-9, TIMP-1, S100B and MMP-9/TIMP-1 ratio after RT (p > 0.05). The verbal learning was improved in post-test for MS + RT group (p < 0.01), although no change were observed for visuospatial memory and information processing speed (p > 0.05). These findings suggest that resistance training can modify some indices of BBB permeability and improve verbal learning in MS-W. The findings may also be beneficial as a non-pharmacological intervention to reduce inflammation.https://doi.org/10.1186/s12868-024-00856-1Blood-brain barrierMatrix metalloproteinasesMultiple sclerosisResistance training |
| spellingShingle | Nasrin Niazi Nezhad Abdolhossein Parnow Kianoosh Khamoushian Rasoul Eslami Julien S Baker Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail BMC Neuroscience Blood-brain barrier Matrix metalloproteinases Multiple sclerosis Resistance training |
| title | Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail |
| title_full | Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail |
| title_fullStr | Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail |
| title_full_unstemmed | Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail |
| title_short | Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail |
| title_sort | resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women a randomized controlled trail |
| topic | Blood-brain barrier Matrix metalloproteinases Multiple sclerosis Resistance training |
| url | https://doi.org/10.1186/s12868-024-00856-1 |
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