Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients
Biocompatibility of heparin-based coating for extracorporeal circuits, the Bioline, was evaluated in cardiac surgery setting. Thirty six CABG pts, aged from 30 to 69 yrs, were randomly perfused with a circuit containing Bioline-coated Quadrox oxygenator (Bioline, n=18) or with a similar non-coated c...
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| Format: | Article |
| Language: | English |
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Meshalkin National Medical Research Center
2015-10-01
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| Series: | Патология кровообращения и кардиохирургия |
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| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/127 |
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| author | И. В. Пономаренко В. М. Шипулин О. Н. Огуркова Т. Е. Суслова |
| author_facet | И. В. Пономаренко В. М. Шипулин О. Н. Огуркова Т. Е. Суслова |
| author_sort | И. В. Пономаренко |
| collection | DOAJ |
| description | Biocompatibility of heparin-based coating for extracorporeal circuits, the Bioline, was evaluated in cardiac surgery setting. Thirty six CABG pts, aged from 30 to 69 yrs, were randomly perfused with a circuit containing Bioline-coated Quadrox oxygenator (Bioline, n=18) or with a similar non-coated circuit (control, n=18). Leukocyte and platelet counts, levels of tumor necrosis factor, interleukin-6 and fibrinogen were assessed in arterial blood before, during and after cardiopulmonary bypass (CPB). Oxygenation and ventilation indices before and after surgery, post-operative chest tube drainage and transfusion volume as well as the duration of assisted ventilation were also measured. A platelet count and fibrinogen dropped less in the Bioline group significantly compared with that in control at the end of CPB (p<0,05) and after protamine administration (p<0,05). A leukocyte count and an interleukin-6 level increased more in controls after CPB (p<0,05) as well as oxygenation and ventilation indices, bleeding volume and intubation time (all p<0,05). Our results suggest surface heparinization with Bioline coating limited to the oxygenator ameliorates the inflammatory response, preserves fibrinogen and platelets, reduces blood loss postoperatively and improves lung function during CPB. |
| first_indexed | 2024-03-12T20:04:32Z |
| format | Article |
| id | doaj.art-2a1258f933cd4702938867869f3083ff |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T20:04:32Z |
| publishDate | 2015-10-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-2a1258f933cd4702938867869f3083ff2023-08-02T02:09:01ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192015-10-01172515610.21688/1681-3472-2013-2-51-56847Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patientsИ. В. Пономаренко0В. М. Шипулин1О. Н. Огуркова2Т. Е. Суслова3ФГБУ «НИИ кардиологии» СО РАМНФГБУ «НИИ кардиологии» СО РАМНФГБУ «НИИ кардиологии» СО РАМНФГБУ «НИИ кардиологии» СО РАМНBiocompatibility of heparin-based coating for extracorporeal circuits, the Bioline, was evaluated in cardiac surgery setting. Thirty six CABG pts, aged from 30 to 69 yrs, were randomly perfused with a circuit containing Bioline-coated Quadrox oxygenator (Bioline, n=18) or with a similar non-coated circuit (control, n=18). Leukocyte and platelet counts, levels of tumor necrosis factor, interleukin-6 and fibrinogen were assessed in arterial blood before, during and after cardiopulmonary bypass (CPB). Oxygenation and ventilation indices before and after surgery, post-operative chest tube drainage and transfusion volume as well as the duration of assisted ventilation were also measured. A platelet count and fibrinogen dropped less in the Bioline group significantly compared with that in control at the end of CPB (p<0,05) and after protamine administration (p<0,05). A leukocyte count and an interleukin-6 level increased more in controls after CPB (p<0,05) as well as oxygenation and ventilation indices, bleeding volume and intubation time (all p<0,05). Our results suggest surface heparinization with Bioline coating limited to the oxygenator ameliorates the inflammatory response, preserves fibrinogen and platelets, reduces blood loss postoperatively and improves lung function during CPB.http://journalmeshalkin.ru/index.php/heartjournal/article/view/127ИСКУССТВЕННОЕ КРОВООБРАЩЕНИЕБИОСОВМЕСТИМЫЕ ПОКРЫТИЯВОСПАЛИТЕЛЬНЫЙ ОТВЕТДЫХАТЕЛЬНЫЕ ИНДЕКСЫ |
| spellingShingle | И. В. Пономаренко В. М. Шипулин О. Н. Огуркова Т. Е. Суслова Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients Патология кровообращения и кардиохирургия ИСКУССТВЕННОЕ КРОВООБРАЩЕНИЕ БИОСОВМЕСТИМЫЕ ПОКРЫТИЯ ВОСПАЛИТЕЛЬНЫЙ ОТВЕТ ДЫХАТЕЛЬНЫЕ ИНДЕКСЫ |
| title | Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients |
| title_full | Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients |
| title_fullStr | Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients |
| title_full_unstemmed | Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients |
| title_short | Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients |
| title_sort | effects of biocompatible extracorporeal bypass circuit coating bioline in cardiac surgery patients |
| topic | ИСКУССТВЕННОЕ КРОВООБРАЩЕНИЕ БИОСОВМЕСТИМЫЕ ПОКРЫТИЯ ВОСПАЛИТЕЛЬНЫЙ ОТВЕТ ДЫХАТЕЛЬНЫЕ ИНДЕКСЫ |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/127 |
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