New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial Properties
A new series of nanostructured materials was obtained by functionalization of SBA-15 mesoporous silica with Ru(II) and Ru(III) complexes bearing Schiff base ligands derived from salicylaldehyde and various amines (1,2-diaminocyclohexane, 1,2-phenylenediamine, ethylenediamine, 1,3-diamino-2-propanol,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/5/1458 |
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| author | Gabriela Marinescu Daniela C. Culita Teodora Mocanu Raul-Augustin Mitran Simona Petrescu Miruna S. Stan Mariana C. Chifiriuc Marcela Popa |
| author_facet | Gabriela Marinescu Daniela C. Culita Teodora Mocanu Raul-Augustin Mitran Simona Petrescu Miruna S. Stan Mariana C. Chifiriuc Marcela Popa |
| author_sort | Gabriela Marinescu |
| collection | DOAJ |
| description | A new series of nanostructured materials was obtained by functionalization of SBA-15 mesoporous silica with Ru(II) and Ru(III) complexes bearing Schiff base ligands derived from salicylaldehyde and various amines (1,2-diaminocyclohexane, 1,2-phenylenediamine, ethylenediamine, 1,3-diamino-2-propanol, N,N-dimethylethylenediamine, 2-aminomethyl-pyridine, and 2-(2-aminoethyl)-pyridine). The incorporation of ruthenium complexes into the porous structure of SBA-15 and the structural, morphological, and textural features of the resulting nanostructured materials were investigated by FTIR, XPS, TG/DTA, zeta potential, SEM, and N<sub>2</sub> physisorption. The ruthenium complex-loaded SBA-15 silica samples were tested against A549 lung tumor cells and MRC-5 normal lung fibroblasts. A dose-dependent effect was observed, with the highest antitumoral efficiency being recorded for the material containing [Ru(Salen)(PPh<sub>3</sub>)Cl] (50%/90% decrease in the A549 cells’ viability at a concentration of 70 μg/mL/200 μg/mL after 24 h incubation). The other hybrid materials have also shown good cytotoxicity against cancer cells, depending on the ligand included in the ruthenium complex. The antibacterial assay revealed an inhibitory effect for all samples, the most active being those containing [Ru(Salen)(PPh<sub>3</sub>)Cl], [Ru(Saldiam)(PPh<sub>3</sub>)Cl], and [Ru(Salaepy)(PPh<sub>3</sub>)Cl], especially against <i>Staphylococcus aureus</i> and <i>Enterococcus faecalis</i> Gram-positive strains. In conclusion, these nanostructured hybrid materials could represent valuable tools for the development of multi-pharmacologically active compounds with antiproliferative, antibacterial, and antibiofilm activity. |
| first_indexed | 2024-03-11T03:24:08Z |
| format | Article |
| id | doaj.art-2a133f2bd7b849cb842c5c7a5e7c719e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T03:24:08Z |
| publishDate | 2023-05-01 |
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| series | Pharmaceutics |
| spelling | doaj.art-2a133f2bd7b849cb842c5c7a5e7c719e2023-11-18T02:51:50ZengMDPI AGPharmaceutics1999-49232023-05-01155145810.3390/pharmaceutics15051458New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial PropertiesGabriela Marinescu0Daniela C. Culita1Teodora Mocanu2Raul-Augustin Mitran3Simona Petrescu4Miruna S. Stan5Mariana C. Chifiriuc6Marcela Popa7Ilie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, RomaniaIlie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, RomaniaIlie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, RomaniaIlie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, RomaniaIlie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, RomaniaFaculty of Biology, University of Bucharest, 90 Panduri Street, 050663 Bucharest, RomaniaFaculty of Biology, University of Bucharest, 90 Panduri Street, 050663 Bucharest, RomaniaFaculty of Biology, University of Bucharest, 90 Panduri Street, 050663 Bucharest, RomaniaA new series of nanostructured materials was obtained by functionalization of SBA-15 mesoporous silica with Ru(II) and Ru(III) complexes bearing Schiff base ligands derived from salicylaldehyde and various amines (1,2-diaminocyclohexane, 1,2-phenylenediamine, ethylenediamine, 1,3-diamino-2-propanol, N,N-dimethylethylenediamine, 2-aminomethyl-pyridine, and 2-(2-aminoethyl)-pyridine). The incorporation of ruthenium complexes into the porous structure of SBA-15 and the structural, morphological, and textural features of the resulting nanostructured materials were investigated by FTIR, XPS, TG/DTA, zeta potential, SEM, and N<sub>2</sub> physisorption. The ruthenium complex-loaded SBA-15 silica samples were tested against A549 lung tumor cells and MRC-5 normal lung fibroblasts. A dose-dependent effect was observed, with the highest antitumoral efficiency being recorded for the material containing [Ru(Salen)(PPh<sub>3</sub>)Cl] (50%/90% decrease in the A549 cells’ viability at a concentration of 70 μg/mL/200 μg/mL after 24 h incubation). The other hybrid materials have also shown good cytotoxicity against cancer cells, depending on the ligand included in the ruthenium complex. The antibacterial assay revealed an inhibitory effect for all samples, the most active being those containing [Ru(Salen)(PPh<sub>3</sub>)Cl], [Ru(Saldiam)(PPh<sub>3</sub>)Cl], and [Ru(Salaepy)(PPh<sub>3</sub>)Cl], especially against <i>Staphylococcus aureus</i> and <i>Enterococcus faecalis</i> Gram-positive strains. In conclusion, these nanostructured hybrid materials could represent valuable tools for the development of multi-pharmacologically active compounds with antiproliferative, antibacterial, and antibiofilm activity.https://www.mdpi.com/1999-4923/15/5/1458ruthenium complexesSBA-15Schiff basesnanostructured hybrid materialslung cancer cellsantitumor activity |
| spellingShingle | Gabriela Marinescu Daniela C. Culita Teodora Mocanu Raul-Augustin Mitran Simona Petrescu Miruna S. Stan Mariana C. Chifiriuc Marcela Popa New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial Properties Pharmaceutics ruthenium complexes SBA-15 Schiff bases nanostructured hybrid materials lung cancer cells antitumor activity |
| title | New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial Properties |
| title_full | New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial Properties |
| title_fullStr | New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial Properties |
| title_full_unstemmed | New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial Properties |
| title_short | New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)/Ru(III) Complexes with Anticancer and Antimicrobial Properties |
| title_sort | new nanostructured materials based on mesoporous silica loaded with ru ii ru iii complexes with anticancer and antimicrobial properties |
| topic | ruthenium complexes SBA-15 Schiff bases nanostructured hybrid materials lung cancer cells antitumor activity |
| url | https://www.mdpi.com/1999-4923/15/5/1458 |
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