Antimicrobial Properties of Silver-Modified Denture Base Resins
The surface quality of denture base resins allows for easy colonization by microorganisms including <i>Candida albicans</i> and <i>Staphylococcus aureus</i>, which cause major diseases of the oral cavity such as denture stomatitis. The widespread use of silver nanoparticles (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/14/2453 |
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| author | Nikola Gligorijević Tatjana Mihajlov-Krstev Milena Kostić Ljubiša Nikolić Nemanja Stanković Vesna Nikolić Ana Dinić Marko Igić Nirit Bernstein |
| author_facet | Nikola Gligorijević Tatjana Mihajlov-Krstev Milena Kostić Ljubiša Nikolić Nemanja Stanković Vesna Nikolić Ana Dinić Marko Igić Nirit Bernstein |
| author_sort | Nikola Gligorijević |
| collection | DOAJ |
| description | The surface quality of denture base resins allows for easy colonization by microorganisms including <i>Candida albicans</i> and <i>Staphylococcus aureus</i>, which cause major diseases of the oral cavity such as denture stomatitis. The widespread use of silver nanoparticles (AgNPs) in various fields of medicine has led to research of their possible application in dentistry, mostly in the prevention of bacterial adhesion, proliferation, and biofilm formation. The aim of the study was to synthesize cold and heat-curing denture base resins modified with AgNPs and AgCl, and evaluate the potential of the modified resins to reduce the growth of <i>C. albicans</i> and <i>S.</i><i>aureus</i>. The produced material was characterized by Fourier transform infrared spectroscopy (FTIR). The antimicrobial potential of the modified material was demonstrated by the disc-diffusion method, microdilution method, and a modified microdilution method (i.e., disk-diffusion method in broth with viable counting). Spectroscopy confirmed the incorporation of biocidal materials into the structure of the denture base resins. The AgCl and AgNPs modified resins showed an antimicrobial effect. The significance of the study is in the potential therapeutic effects of the modified materials for prevention and threating staphylococci and candida in elderly patients, who are in most cases denture wearers and have a greater susceptibility to develop opportunistic infections. Modified denture base resins can significantly reduce the presence of infection at the point of contact between the denture and the mucous membrane of the prosthetic restoration. Biological tests of modified denture base resins will follow. |
| first_indexed | 2024-03-09T06:06:04Z |
| format | Article |
| id | doaj.art-2a167591ef1b4a11a7215d1ddd4ce7ab |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T06:06:04Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-2a167591ef1b4a11a7215d1ddd4ce7ab2023-12-03T12:03:34ZengMDPI AGNanomaterials2079-49912022-07-011214245310.3390/nano12142453Antimicrobial Properties of Silver-Modified Denture Base ResinsNikola Gligorijević0Tatjana Mihajlov-Krstev1Milena Kostić2Ljubiša Nikolić3Nemanja Stanković4Vesna Nikolić5Ana Dinić6Marko Igić7Nirit Bernstein8Department of Prosthodontics, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaFaculty of Sciences and Mathematics, University of Niš, 18000 Niš, SerbiaDepartment of Prosthodontics, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaFaculty of Technology, University of Niš, 16000 Leskovac, SerbiaInstitute for Public Health Niš, 18000 Niš, SerbiaFaculty of Technology, University of Niš, 16000 Leskovac, SerbiaFaculty of Technology, University of Niš, 16000 Leskovac, SerbiaDepartment of Prosthodontics, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaInstitute of Soil Water and Environmental Sciences, Volcani Center, Rishon LeZion 7505001, IsraelThe surface quality of denture base resins allows for easy colonization by microorganisms including <i>Candida albicans</i> and <i>Staphylococcus aureus</i>, which cause major diseases of the oral cavity such as denture stomatitis. The widespread use of silver nanoparticles (AgNPs) in various fields of medicine has led to research of their possible application in dentistry, mostly in the prevention of bacterial adhesion, proliferation, and biofilm formation. The aim of the study was to synthesize cold and heat-curing denture base resins modified with AgNPs and AgCl, and evaluate the potential of the modified resins to reduce the growth of <i>C. albicans</i> and <i>S.</i><i>aureus</i>. The produced material was characterized by Fourier transform infrared spectroscopy (FTIR). The antimicrobial potential of the modified material was demonstrated by the disc-diffusion method, microdilution method, and a modified microdilution method (i.e., disk-diffusion method in broth with viable counting). Spectroscopy confirmed the incorporation of biocidal materials into the structure of the denture base resins. The AgCl and AgNPs modified resins showed an antimicrobial effect. The significance of the study is in the potential therapeutic effects of the modified materials for prevention and threating staphylococci and candida in elderly patients, who are in most cases denture wearers and have a greater susceptibility to develop opportunistic infections. Modified denture base resins can significantly reduce the presence of infection at the point of contact between the denture and the mucous membrane of the prosthetic restoration. Biological tests of modified denture base resins will follow.https://www.mdpi.com/2079-4991/12/14/2453denture base resinssilver nanoparticlesAgNPsantimicrobial effect |
| spellingShingle | Nikola Gligorijević Tatjana Mihajlov-Krstev Milena Kostić Ljubiša Nikolić Nemanja Stanković Vesna Nikolić Ana Dinić Marko Igić Nirit Bernstein Antimicrobial Properties of Silver-Modified Denture Base Resins Nanomaterials denture base resins silver nanoparticles AgNPs antimicrobial effect |
| title | Antimicrobial Properties of Silver-Modified Denture Base Resins |
| title_full | Antimicrobial Properties of Silver-Modified Denture Base Resins |
| title_fullStr | Antimicrobial Properties of Silver-Modified Denture Base Resins |
| title_full_unstemmed | Antimicrobial Properties of Silver-Modified Denture Base Resins |
| title_short | Antimicrobial Properties of Silver-Modified Denture Base Resins |
| title_sort | antimicrobial properties of silver modified denture base resins |
| topic | denture base resins silver nanoparticles AgNPs antimicrobial effect |
| url | https://www.mdpi.com/2079-4991/12/14/2453 |
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