Nutritional effects on mucosal integrity and immune function
The intestinal mucosal barrier plays a critical role in maintaining the integrity of the gastrointestinal (GI) tract and protecting the body from harmful toxins and pathogens. Nutrition additionally serves as a vital component in maintaining bodily homeostasis. Macronutrients, micronutrients, and sp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2024-02-01
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| Series: | Exploration of Immunology |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/ei/Article/1003130 |
| _version_ | 1797291623158120448 |
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| author | Lindsey B. Cundra Manasa Vallabhaneni Kevin Houston Michael Saadeh Alejandra Vargas Steven M. D’Souza David A. Johnson |
| author_facet | Lindsey B. Cundra Manasa Vallabhaneni Kevin Houston Michael Saadeh Alejandra Vargas Steven M. D’Souza David A. Johnson |
| author_sort | Lindsey B. Cundra |
| collection | DOAJ |
| description | The intestinal mucosal barrier plays a critical role in maintaining the integrity of the gastrointestinal (GI) tract and protecting the body from harmful toxins and pathogens. Nutrition additionally serves as a vital component in maintaining bodily homeostasis. Macronutrients, micronutrients, and specific dietary habits exert profound effects on the immune system. The complex interactions of the immune system reflect a multifaceted, integrated epithelial and immune cell-mediated regulatory system. While several factors can influence the intestinal mucosal barrier and its pro- and anti-inflammatory processes, such as myeloid cell, regulatory T cell (Treg), or intraepithelial lymphocyte populations, there is growing evidence that macronutrients play an essential role in regulating its function. Herein this is a review of the peer-reviewed literature pertaining to dietary effects on mucosal integrity, including intraepithelial lymphocyte populations and immune function. This review is intended to explore the underlying mechanisms by which macronutrients impact and modulate the mucosal immune system. |
| first_indexed | 2024-03-07T19:39:21Z |
| format | Article |
| id | doaj.art-2a17e752bf6e44b7b1e812a12af78f4f |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-03-07T19:39:21Z |
| publishDate | 2024-02-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-2a17e752bf6e44b7b1e812a12af78f4f2024-02-29T05:48:36ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552024-02-01419010510.37349/ei.2024.00130Nutritional effects on mucosal integrity and immune functionLindsey B. Cundra0https://orcid.org/0000-0003-2162-4739Manasa Vallabhaneni1https://orcid.org/0000-0003-0232-065XKevin Houston2https://orcid.org/0000-0002-8441-0132Michael Saadeh3https://orcid.org/0000-0001-9314-5361Alejandra Vargas4Steven M. D’Souza5https://orcid.org/0000-0003-3772-2616David A. Johnson6https://orcid.org/0000-0002-8737-0711Department of Internal Medicine, Georgetown University, Washington DC 20057, USADepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23501, USADepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23284, USADepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23501, USADepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23501, USADepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23501, USADepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23501, USAThe intestinal mucosal barrier plays a critical role in maintaining the integrity of the gastrointestinal (GI) tract and protecting the body from harmful toxins and pathogens. Nutrition additionally serves as a vital component in maintaining bodily homeostasis. Macronutrients, micronutrients, and specific dietary habits exert profound effects on the immune system. The complex interactions of the immune system reflect a multifaceted, integrated epithelial and immune cell-mediated regulatory system. While several factors can influence the intestinal mucosal barrier and its pro- and anti-inflammatory processes, such as myeloid cell, regulatory T cell (Treg), or intraepithelial lymphocyte populations, there is growing evidence that macronutrients play an essential role in regulating its function. Herein this is a review of the peer-reviewed literature pertaining to dietary effects on mucosal integrity, including intraepithelial lymphocyte populations and immune function. This review is intended to explore the underlying mechanisms by which macronutrients impact and modulate the mucosal immune system.https://www.explorationpub.com/Journals/ei/Article/1003130inflammatory bowel diseasedietmicrobiotaimmunityintestinal barrier |
| spellingShingle | Lindsey B. Cundra Manasa Vallabhaneni Kevin Houston Michael Saadeh Alejandra Vargas Steven M. D’Souza David A. Johnson Nutritional effects on mucosal integrity and immune function Exploration of Immunology inflammatory bowel disease diet microbiota immunity intestinal barrier |
| title | Nutritional effects on mucosal integrity and immune function |
| title_full | Nutritional effects on mucosal integrity and immune function |
| title_fullStr | Nutritional effects on mucosal integrity and immune function |
| title_full_unstemmed | Nutritional effects on mucosal integrity and immune function |
| title_short | Nutritional effects on mucosal integrity and immune function |
| title_sort | nutritional effects on mucosal integrity and immune function |
| topic | inflammatory bowel disease diet microbiota immunity intestinal barrier |
| url | https://www.explorationpub.com/Journals/ei/Article/1003130 |
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