“Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.”
Abstract Background Patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) have been under-represented in studies about safety of the COVID-19 immunization. We aimed to inquire about the safety and tolerability of COVID-19 immunization in this population....
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-023-00911-x |
| _version_ | 1797453596791406592 |
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| author | Mariana Correia Marques Subrata Paul Carol Lake Ly-Lan Bergeron Rashmi Sinha Luciana Peixoto Marinka Twilt Michael J. Ombrello |
| author_facet | Mariana Correia Marques Subrata Paul Carol Lake Ly-Lan Bergeron Rashmi Sinha Luciana Peixoto Marinka Twilt Michael J. Ombrello |
| author_sort | Mariana Correia Marques |
| collection | DOAJ |
| description | Abstract Background Patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) have been under-represented in studies about safety of the COVID-19 immunization. We aimed to inquire about the safety and tolerability of COVID-19 immunization in this population. Methods An anonymous online survey on closed Facebook groups for patients and parents with self-reported sJIA/AOSD was posted from June 27th until August 30th, 2022. Continuous variables were analyzed using t-tests or the Mann-Whitney U test if non-normally distributed. Fisher`s tests were used for categorical variables. Results Of a total of 167 responses, 17 were excluded. Ninety-nine patients received the COVID-19 immunization, and 51 patients did not. Patients in both immunized and unimmunized groups had a similar history of disease complications such as macrophage activation syndrome (50% vs. 49%), lung disease (17% vs. 29%), arthritis (51% vs. 50%), and pericarditis/myocarditis (10% vs. 8%). Unimmunized patients were younger (median age 8 yo vs. 12 yo, p < 0.001) and had a higher incidence of a history of disease flare or severe side effects with other immunizations (24% vs. 4%, p < 0.001). Thirty-nine patients reported mostly mild immunization side effects. Severe side effects included 6 reports of disease flare and 2 reports of cardiac side effects (pericarditis and atrial fibrillation). Seven patients reported side effects lasting ≥ 8 days. Three patients developed AOSD following COVID-19 immunization, and 2 of them had the only hospital admissions for immunization side effects. Regarding COVID-19 infection, 46 patients were infected without full immunization, and 33 were infected after 2 doses of immunization. There was one hospitalization in the immunized group, compared to one ICU admission leading to death in the non-immunized group. There was a trend (p > 0.05) toward a higher risk of disease flare after COVID-19 infection among non-immunized patients (43%), compared to immunized patients (24%). Conclusions The COVID-19 immunization was well tolerated by sJIA/AOSD patients even in this group of patients with severe disease. There was a low incidence of disease flare with immunization. Most immunization side effects were mild and lasted < 7 days. The only ICU admission and death from COVID-19 infection occurred in unimmunized subjects. |
| first_indexed | 2024-03-09T15:24:08Z |
| format | Article |
| id | doaj.art-2a1897924c78496fbaec7d8f86fafbbd |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-03-09T15:24:08Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-2a1897924c78496fbaec7d8f86fafbbd2023-11-26T12:35:49ZengBMCPediatric Rheumatology Online Journal1546-00962023-11-0121111010.1186/s12969-023-00911-x“Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.”Mariana Correia Marques0Subrata Paul1Carol Lake2Ly-Lan Bergeron3Rashmi Sinha4Luciana Peixoto5Marinka Twilt6Michael J. Ombrello7Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin DiseasesIntegrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIHTranslational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin DiseasesTranslational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin DiseasesSystemic JIA FoundationSystemic JIA FoundationSection of Rheumatology, Department of Pediatrics, Alberta Children’s Hospital, Cumming School of Medicine, University of CalgaryTranslational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin DiseasesAbstract Background Patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) have been under-represented in studies about safety of the COVID-19 immunization. We aimed to inquire about the safety and tolerability of COVID-19 immunization in this population. Methods An anonymous online survey on closed Facebook groups for patients and parents with self-reported sJIA/AOSD was posted from June 27th until August 30th, 2022. Continuous variables were analyzed using t-tests or the Mann-Whitney U test if non-normally distributed. Fisher`s tests were used for categorical variables. Results Of a total of 167 responses, 17 were excluded. Ninety-nine patients received the COVID-19 immunization, and 51 patients did not. Patients in both immunized and unimmunized groups had a similar history of disease complications such as macrophage activation syndrome (50% vs. 49%), lung disease (17% vs. 29%), arthritis (51% vs. 50%), and pericarditis/myocarditis (10% vs. 8%). Unimmunized patients were younger (median age 8 yo vs. 12 yo, p < 0.001) and had a higher incidence of a history of disease flare or severe side effects with other immunizations (24% vs. 4%, p < 0.001). Thirty-nine patients reported mostly mild immunization side effects. Severe side effects included 6 reports of disease flare and 2 reports of cardiac side effects (pericarditis and atrial fibrillation). Seven patients reported side effects lasting ≥ 8 days. Three patients developed AOSD following COVID-19 immunization, and 2 of them had the only hospital admissions for immunization side effects. Regarding COVID-19 infection, 46 patients were infected without full immunization, and 33 were infected after 2 doses of immunization. There was one hospitalization in the immunized group, compared to one ICU admission leading to death in the non-immunized group. There was a trend (p > 0.05) toward a higher risk of disease flare after COVID-19 infection among non-immunized patients (43%), compared to immunized patients (24%). Conclusions The COVID-19 immunization was well tolerated by sJIA/AOSD patients even in this group of patients with severe disease. There was a low incidence of disease flare with immunization. Most immunization side effects were mild and lasted < 7 days. The only ICU admission and death from COVID-19 infection occurred in unimmunized subjects.https://doi.org/10.1186/s12969-023-00911-xCOVID-19ImmunizationVaccineSystemic Juvenile idiopathic arthritisAdult-onset Still’s DiseasesJIA |
| spellingShingle | Mariana Correia Marques Subrata Paul Carol Lake Ly-Lan Bergeron Rashmi Sinha Luciana Peixoto Marinka Twilt Michael J. Ombrello “Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.” Pediatric Rheumatology Online Journal COVID-19 Immunization Vaccine Systemic Juvenile idiopathic arthritis Adult-onset Still’s Disease sJIA |
| title | “Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.” |
| title_full | “Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.” |
| title_fullStr | “Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.” |
| title_full_unstemmed | “Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.” |
| title_short | “Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.” |
| title_sort | online survey of covid 19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult onset still s disease |
| topic | COVID-19 Immunization Vaccine Systemic Juvenile idiopathic arthritis Adult-onset Still’s Disease sJIA |
| url | https://doi.org/10.1186/s12969-023-00911-x |
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