Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia
Background: Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated. Methods: MPV and plateletcrit levels of both CLL and contro...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2023-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582302274O.pdf |
| _version_ | 1797853167214395392 |
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| author | Ozbalci Demircan Alanoglu Emine Guchan Findos Eda Eroglu Hande Nur |
| author_facet | Ozbalci Demircan Alanoglu Emine Guchan Findos Eda Eroglu Hande Nur |
| author_sort | Ozbalci Demircan |
| collection | DOAJ |
| description | Background: Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated. Methods: MPV and plateletcrit levels of both CLL and control group were compared and then in CLL patients, additional diseases, leukocyte count, platelet count, lactate dehydrogenase, Rai stage, progression-free and overall survival, mutations, if any, and chemotherapy, if any, were recorded. Then, the relationship between MPV and plateletcrit values and these parameters were evaluated in CLL patients. Results: Platelet and plateletcrit values were found to be significantly lower in CLL patients than the control group (p<0.001) for both. Plateletcrit and MPV values of patients who did not receive chemotherapy were higher than those who received chemotherapy (p=0.03, p=0.02, respectively). Being over 75 years old, plateletcrit value less than 0.1565 %, platelet level below 175 x 109/L, and leukocyte count greater than 53.5 x 109/L was found to significantly reduce overall survival. Male gender, each stage increase, plateletcrit less than 0.1565 % and leukocyte count greater than 53.5 x 109/L was related to reduce treatment-free survival in CLL patients. Conclusions: Plateletcrit can be a viable prognostic marker for defining both treatment free and overall survival. |
| first_indexed | 2024-04-09T19:46:14Z |
| format | Article |
| id | doaj.art-2a1930ac8ecd469c92f7b508d2f48acc |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-04-09T19:46:14Z |
| publishDate | 2023-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-2a1930ac8ecd469c92f7b508d2f48acc2023-04-03T15:53:00ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662023-01-014222742811452-82582302274OLow plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemiaOzbalci Demircan0https://orcid.org/0000-0002-9635-3091Alanoglu Emine Guchan1Findos Eda2Eroglu Hande Nur3Suleyman Demirel University Research and Education Hospital, Department of Hematology, Isparta, TurkeySuleyman Demirel University Research and Education Hospital, Department of Hematology, Isparta, TurkeySuleyman Demirel University Research and Education Hospital, Department of Internal Medicine, Isparta, TurkeySuleyman Demirel University Research and Education Hospital, Department of Public Health, Isparta, TurkeyBackground: Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated. Methods: MPV and plateletcrit levels of both CLL and control group were compared and then in CLL patients, additional diseases, leukocyte count, platelet count, lactate dehydrogenase, Rai stage, progression-free and overall survival, mutations, if any, and chemotherapy, if any, were recorded. Then, the relationship between MPV and plateletcrit values and these parameters were evaluated in CLL patients. Results: Platelet and plateletcrit values were found to be significantly lower in CLL patients than the control group (p<0.001) for both. Plateletcrit and MPV values of patients who did not receive chemotherapy were higher than those who received chemotherapy (p=0.03, p=0.02, respectively). Being over 75 years old, plateletcrit value less than 0.1565 %, platelet level below 175 x 109/L, and leukocyte count greater than 53.5 x 109/L was found to significantly reduce overall survival. Male gender, each stage increase, plateletcrit less than 0.1565 % and leukocyte count greater than 53.5 x 109/L was related to reduce treatment-free survival in CLL patients. Conclusions: Plateletcrit can be a viable prognostic marker for defining both treatment free and overall survival.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582302274O.pdfplateletcritchronic lymphocytic leukaemiaprognosisoverall survival |
| spellingShingle | Ozbalci Demircan Alanoglu Emine Guchan Findos Eda Eroglu Hande Nur Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia Journal of Medical Biochemistry plateletcrit chronic lymphocytic leukaemia prognosis overall survival |
| title | Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia |
| title_full | Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia |
| title_fullStr | Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia |
| title_full_unstemmed | Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia |
| title_short | Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia |
| title_sort | low plateletcrit is associated with reduced progression free and overall survival in chronic lymphocytic leukemia |
| topic | plateletcrit chronic lymphocytic leukaemia prognosis overall survival |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582302274O.pdf |
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