The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i>
<i>Pseudomonas aeruginosa</i> is a common, opportunistic bacterial pathogen among patients with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these diseases, <span style="font-variant: small-caps;">l</span>-ornithine, a non...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/2/264 |
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| author | Basanta Dhodary Inmaculada Sampedro Shekooh Behroozian Victor Borza Stephanie Her Jane E. Hill |
| author_facet | Basanta Dhodary Inmaculada Sampedro Shekooh Behroozian Victor Borza Stephanie Her Jane E. Hill |
| author_sort | Basanta Dhodary |
| collection | DOAJ |
| description | <i>Pseudomonas aeruginosa</i> is a common, opportunistic bacterial pathogen among patients with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these diseases, <span style="font-variant: small-caps;">l</span>-ornithine, a non-proteinogenic amino acid, becomes more abundant. <i>P. aeruginosa</i> is chemotactic towards other proteinogenic amino acids. Here, we evaluated the chemotaxis response of <i>P. aeruginosa</i> towards <span style="font-variant: small-caps;">l</span>-ornithine. Our results show that <span style="font-variant: small-caps;">l</span>-ornithine serves as a chemoattractant for several strains of <i>P. aeruginosa</i>, including clinical isolates, and that the chemoreceptors involved in <i>P. aeruginosa</i> PAO1 are PctA and PctB. It seems likely that <i>P. aeruginosa</i>’s chemotactic response to <span style="font-variant: small-caps;">l</span>-ornithine might be a common feature and thus could potentially contribute to pathogenesis processes during colonization and infection scenarios. |
| first_indexed | 2024-03-09T21:23:27Z |
| format | Article |
| id | doaj.art-2a19dd34a3ba4f28a5af38bce966536c |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T21:23:27Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-2a19dd34a3ba4f28a5af38bce966536c2023-11-23T21:13:25ZengMDPI AGMicroorganisms2076-26072022-01-0110226410.3390/microorganisms10020264The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i>Basanta Dhodary0Inmaculada Sampedro1Shekooh Behroozian2Victor Borza3Stephanie Her4Jane E. Hill5School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, CanadaThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USASchool of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, CanadaThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USASchool of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada<i>Pseudomonas aeruginosa</i> is a common, opportunistic bacterial pathogen among patients with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these diseases, <span style="font-variant: small-caps;">l</span>-ornithine, a non-proteinogenic amino acid, becomes more abundant. <i>P. aeruginosa</i> is chemotactic towards other proteinogenic amino acids. Here, we evaluated the chemotaxis response of <i>P. aeruginosa</i> towards <span style="font-variant: small-caps;">l</span>-ornithine. Our results show that <span style="font-variant: small-caps;">l</span>-ornithine serves as a chemoattractant for several strains of <i>P. aeruginosa</i>, including clinical isolates, and that the chemoreceptors involved in <i>P. aeruginosa</i> PAO1 are PctA and PctB. It seems likely that <i>P. aeruginosa</i>’s chemotactic response to <span style="font-variant: small-caps;">l</span>-ornithine might be a common feature and thus could potentially contribute to pathogenesis processes during colonization and infection scenarios.https://www.mdpi.com/2076-2607/10/2/264chemotaxis<span style="font-variant: small-caps">l</span>-ornithine<i>Pseudomonas aeruginosa</i>chemoreceptor |
| spellingShingle | Basanta Dhodary Inmaculada Sampedro Shekooh Behroozian Victor Borza Stephanie Her Jane E. Hill The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i> Microorganisms chemotaxis <span style="font-variant: small-caps">l</span>-ornithine <i>Pseudomonas aeruginosa</i> chemoreceptor |
| title | The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i> |
| title_full | The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i> |
| title_fullStr | The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i> |
| title_full_unstemmed | The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i> |
| title_short | The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i> |
| title_sort | arginine catabolism derived amino acid span style font variant small caps l span ornithine is a chemoattractant for i pseudomonas aeruginosa i |
| topic | chemotaxis <span style="font-variant: small-caps">l</span>-ornithine <i>Pseudomonas aeruginosa</i> chemoreceptor |
| url | https://www.mdpi.com/2076-2607/10/2/264 |
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