Cryptotanshinone inhibits ovarian tumor growth and metastasis by degrading c-Myc and attenuating the FAK signaling pathway

Cryptotanshinone inhibits ovarian tumor growth and metastasis by degrading c-Myc and attenuating the FAK signaling pathway

Cryptotanshinone (CT), a natural compound derived from Salvia miltiorrhiza Bunge that is also known as the traditional Chinese medicine Danshen, exhibits antitumor activity in various cancers. However, it remains unclear whether CT has a potential therapeutic benefit against ovarian cancers. The aim...

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Bibliographic Details
Main Authors: Huijun Guo, Wenjing Zhang, Jiaxing Wang, Guannan Zhao, Yaohong Wang, Bing-Mei Zhu, Peixin Dong, Hidemichi Watari, Baojin Wang, Wei Li, Gabor Tigyi, Junming Yue
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cryptotanshinone
ovarian cancer
c-Myc
FAK
ubiquitination
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.959518/full

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