Topical Neck Cooling Prolongs Survival of Rats with Intra-Abdominal Feculent Sepsis by Activation of the Vagus Nerve

Topical Neck Cooling Prolongs Survival of Rats with Intra-Abdominal Feculent Sepsis by Activation of the Vagus Nerve

Global hypothermia prolongs survival in rats with intraabdominal feculent sepsis by inhibiting inflammatory responses. We hypothesized that topical neck cooling (TNC) has similar benefits. Septic shock was induced by cecal ligation and incision (CLI) in Sprague Dawley rats. Rats were randomized to s...

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Bibliographic Details
Main Authors: Aimee Y. Zhang, Katherine M. Marsh, Radhika Rastogi, Di Wu, Eric J. Charles, Irving L. Kron, Robert G. Sawyer, Zequan Yang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
intraabdominal sepsis
shock
topical hypothermia
neck cooling
vagus nerve
inflammatory response
Online Access:https://www.mdpi.com/1422-0067/22/18/9828

Internet

https://www.mdpi.com/1422-0067/22/18/9828

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