Identifying common genetic risk factors of diabetic neuropathies

Type 2 diabetes mellitus (T2DM) is a global public health problem of epidemic proportions, with 60-70% of affected individuals suffering from associated neurovascular complications that act on multiple organ systems. The most common and clinically significant neuropathies of T2DM include uremic neur...

Full description

Bibliographic Details
Main Authors: Ini-Isabee eWitzel, Herbert F. Jelinek, Kinda eKhalaf, Sungmun eLee, Ahsan eKhandoker, Habiba eAlsafar
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00088/full
_version_ 1818516290004844544
author Ini-Isabee eWitzel
Herbert F. Jelinek
Herbert F. Jelinek
Kinda eKhalaf
Sungmun eLee
Ahsan eKhandoker
Habiba eAlsafar
author_facet Ini-Isabee eWitzel
Herbert F. Jelinek
Herbert F. Jelinek
Kinda eKhalaf
Sungmun eLee
Ahsan eKhandoker
Habiba eAlsafar
author_sort Ini-Isabee eWitzel
collection DOAJ
description Type 2 diabetes mellitus (T2DM) is a global public health problem of epidemic proportions, with 60-70% of affected individuals suffering from associated neurovascular complications that act on multiple organ systems. The most common and clinically significant neuropathies of T2DM include uremic neuropathy, peripheral neuropathy, and cardiac autonomic neuropathy. These conditions seriously impact an individual’s quality of life and significantly increase the risk of morbidity and mortality. Although advances in gene sequencing technologies have identified several genetic variants that may regulate the development and progression of T2DM, little is known about whether or not and how these genetic variants are associated with diabetic neuropathy. Significant missing heritability data and complex disease etiologies remain to be explained. This article is the first to provide a review of the genetic risk variants implicated in the diabetic neuropathies, to highlight potential commonalities. We thereby aim to contribute to the creation of a genetic-metabolic model that will help elucidate the cause of diabetic neuropathies, evaluate a patient’s risk profile, and ultimately facilitate preventative and targeted treatment for the individual.
first_indexed 2024-12-11T00:40:06Z
format Article
id doaj.art-2a202f8ae0524bcf89ef3268a1e36a09
institution Directory Open Access Journal
issn 1664-2392
language English
last_indexed 2024-12-11T00:40:06Z
publishDate 2015-05-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Endocrinology
spelling doaj.art-2a202f8ae0524bcf89ef3268a1e36a092022-12-22T01:26:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922015-05-01610.3389/fendo.2015.00088141587Identifying common genetic risk factors of diabetic neuropathiesIni-Isabee eWitzel0Herbert F. Jelinek1Herbert F. Jelinek2Kinda eKhalaf3Sungmun eLee4Ahsan eKhandoker5Habiba eAlsafar6Khalifa University of Science, Technology and Research (KUSTAR)Macquarie UniversityCharles Sturt UniversityKhalifa University of Science, Technology and Research (KUSTAR)Khalifa University of Science, Technology and Research (KUSTAR)Khalifa University of Science, Technology and Research (KUSTAR)Khalifa University of Science, Technology and Research (KUSTAR)Type 2 diabetes mellitus (T2DM) is a global public health problem of epidemic proportions, with 60-70% of affected individuals suffering from associated neurovascular complications that act on multiple organ systems. The most common and clinically significant neuropathies of T2DM include uremic neuropathy, peripheral neuropathy, and cardiac autonomic neuropathy. These conditions seriously impact an individual’s quality of life and significantly increase the risk of morbidity and mortality. Although advances in gene sequencing technologies have identified several genetic variants that may regulate the development and progression of T2DM, little is known about whether or not and how these genetic variants are associated with diabetic neuropathy. Significant missing heritability data and complex disease etiologies remain to be explained. This article is the first to provide a review of the genetic risk variants implicated in the diabetic neuropathies, to highlight potential commonalities. We thereby aim to contribute to the creation of a genetic-metabolic model that will help elucidate the cause of diabetic neuropathies, evaluate a patient’s risk profile, and ultimately facilitate preventative and targeted treatment for the individual.http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00088/fullDiabetic neuropathydiabetic complicationsgenetic factorsType 2 diabetes mellitus (T2DM)cardiac autonomic neuropathyDiabetic peripheral neuropathy
spellingShingle Ini-Isabee eWitzel
Herbert F. Jelinek
Herbert F. Jelinek
Kinda eKhalaf
Sungmun eLee
Ahsan eKhandoker
Habiba eAlsafar
Identifying common genetic risk factors of diabetic neuropathies
Frontiers in Endocrinology
Diabetic neuropathy
diabetic complications
genetic factors
Type 2 diabetes mellitus (T2DM)
cardiac autonomic neuropathy
Diabetic peripheral neuropathy
title Identifying common genetic risk factors of diabetic neuropathies
title_full Identifying common genetic risk factors of diabetic neuropathies
title_fullStr Identifying common genetic risk factors of diabetic neuropathies
title_full_unstemmed Identifying common genetic risk factors of diabetic neuropathies
title_short Identifying common genetic risk factors of diabetic neuropathies
title_sort identifying common genetic risk factors of diabetic neuropathies
topic Diabetic neuropathy
diabetic complications
genetic factors
Type 2 diabetes mellitus (T2DM)
cardiac autonomic neuropathy
Diabetic peripheral neuropathy
url http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00088/full
work_keys_str_mv AT iniisabeeewitzel identifyingcommongeneticriskfactorsofdiabeticneuropathies
AT herbertfjelinek identifyingcommongeneticriskfactorsofdiabeticneuropathies
AT herbertfjelinek identifyingcommongeneticriskfactorsofdiabeticneuropathies
AT kindaekhalaf identifyingcommongeneticriskfactorsofdiabeticneuropathies
AT sungmunelee identifyingcommongeneticriskfactorsofdiabeticneuropathies
AT ahsanekhandoker identifyingcommongeneticriskfactorsofdiabeticneuropathies
AT habibaealsafar identifyingcommongeneticriskfactorsofdiabeticneuropathies