The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study
Abstract Background Interstitial lung disease (ILD) remains one of the most important causes of morbidity and mortality in patients with Connective Tissue Diseases (CTD). This study evaluated the impact of hospitalization on mortality in an ethnically and racially diverse cohort of CTD-ILD patients....
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42358-023-00343-x |
| _version_ | 1797362695719092224 |
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| author | Anna Korogodina Navneet Kaur Xianhong Xie Adhya Mehta Krystal L. Cleven Bibi Ayesha Anand Kumthekar |
| author_facet | Anna Korogodina Navneet Kaur Xianhong Xie Adhya Mehta Krystal L. Cleven Bibi Ayesha Anand Kumthekar |
| author_sort | Anna Korogodina |
| collection | DOAJ |
| description | Abstract Background Interstitial lung disease (ILD) remains one of the most important causes of morbidity and mortality in patients with Connective Tissue Diseases (CTD). This study evaluated the impact of hospitalization on mortality in an ethnically and racially diverse cohort of CTD-ILD patients. Methods We conducted a medical records review study at Montefiore Medical Center, Bronx, NY. We included 96 patients and collected data on demographic characteristics, reasons for hospitalization, length of stay, immunosuppressant therapy use, and mortality. We stratified our patients into two cohorts: hospitalized and non-hospitalized. The hospitalized cohort was further subdivided into cardiopulmonary and non-cardiopulmonary admissions. Two-sample tests or Wilcoxon’s rank sum tests for continuous variables and Chi-square or Fisher’s exact tests for categorical variables were used for analyses as deemed appropriate. Results We identified 213 patients with CTD-ILD. Out of them, 96 patients met the study’s inclusion criteria. The majority of patients were females (79%), and self-identified as Hispanic (54%) and Black (40%). The most common CTDs were rheumatoid arthritis (RA) (29%), inflammatory myositis (22%), and systemic sclerosis (15%). The majority (76%) of patients required at least one hospitalization. In the non-hospitalized group, no deaths were observed, however we noted significant increase of mortality risk in hospitalized group (p = 0.02). We also observed that prolonged hospital stay (> 7 days) as well as older age and male sex were associated with increased mortality. Conclusions Prolonged (> 7 days) hospital stay and hospitalization for cardiopulmonary causes, as well as older age and male sex were associated with an increased mortality risk in our cohort of CTD-ILD patients. |
| first_indexed | 2024-03-08T16:11:08Z |
| format | Article |
| id | doaj.art-2a215448922f49008567986f9d975e65 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-03-08T16:11:08Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-2a215448922f49008567986f9d975e652024-01-07T12:55:20ZengBMCAdvances in Rheumatology2523-31062024-01-016411710.1186/s42358-023-00343-xThe impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review studyAnna Korogodina0Navneet Kaur1Xianhong Xie2Adhya Mehta3Krystal L. Cleven4Bibi Ayesha5Anand Kumthekar6Department of Medicine, Montefiore Medical Center-Wakefield/Albert Einstein College of MedicineTouro University Medical GroupDepartment of Epidemiology & Population Health, Albert Einstein College of MedicineDepartment of Internal Medicine, Jacobi Medical Center, Albert Einstein College of MedicineDivision of Pulmonary Medicine, Montefiore Medical Center/Albert Einstein College of MedicineDivision of Rheumatology, Montefiore Medical Center/Albert Einstein College of MedicineDivision of Rheumatology, Montefiore Medical Center/Albert Einstein College of MedicineAbstract Background Interstitial lung disease (ILD) remains one of the most important causes of morbidity and mortality in patients with Connective Tissue Diseases (CTD). This study evaluated the impact of hospitalization on mortality in an ethnically and racially diverse cohort of CTD-ILD patients. Methods We conducted a medical records review study at Montefiore Medical Center, Bronx, NY. We included 96 patients and collected data on demographic characteristics, reasons for hospitalization, length of stay, immunosuppressant therapy use, and mortality. We stratified our patients into two cohorts: hospitalized and non-hospitalized. The hospitalized cohort was further subdivided into cardiopulmonary and non-cardiopulmonary admissions. Two-sample tests or Wilcoxon’s rank sum tests for continuous variables and Chi-square or Fisher’s exact tests for categorical variables were used for analyses as deemed appropriate. Results We identified 213 patients with CTD-ILD. Out of them, 96 patients met the study’s inclusion criteria. The majority of patients were females (79%), and self-identified as Hispanic (54%) and Black (40%). The most common CTDs were rheumatoid arthritis (RA) (29%), inflammatory myositis (22%), and systemic sclerosis (15%). The majority (76%) of patients required at least one hospitalization. In the non-hospitalized group, no deaths were observed, however we noted significant increase of mortality risk in hospitalized group (p = 0.02). We also observed that prolonged hospital stay (> 7 days) as well as older age and male sex were associated with increased mortality. Conclusions Prolonged (> 7 days) hospital stay and hospitalization for cardiopulmonary causes, as well as older age and male sex were associated with an increased mortality risk in our cohort of CTD-ILD patients.https://doi.org/10.1186/s42358-023-00343-xInterstitial lung DiseaseConnective tissue DiseasesHospitalizationMortality |
| spellingShingle | Anna Korogodina Navneet Kaur Xianhong Xie Adhya Mehta Krystal L. Cleven Bibi Ayesha Anand Kumthekar The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study Advances in Rheumatology Interstitial lung Disease Connective tissue Diseases Hospitalization Mortality |
| title | The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study |
| title_full | The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study |
| title_fullStr | The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study |
| title_full_unstemmed | The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study |
| title_short | The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study |
| title_sort | impact of hospitalization on mortality in patients with connective tissue disease associated interstitial lung disease a medical records review study |
| topic | Interstitial lung Disease Connective tissue Diseases Hospitalization Mortality |
| url | https://doi.org/10.1186/s42358-023-00343-x |
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