Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis
Background Immunomodulatory therapy may help prevent heart failure (HF). Data on immune cells and myocardial remodeling in older adults with cardiovascular risk factors are limited.Methods In the Multi-Ethnic Study of Atherosclerosis cohort, 869 adults had 19 peripheral immune cell subsets measured...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical investigation
2021-07-01
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| Series: | JCI Insight |
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.149193 |
| _version_ | 1818236592393814016 |
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| author | Arjun Sinha Adovich S. Rivera Margaret F. Doyle Colleen Sitlani Alison Fohner Sally A. Huber Nels C. Olson Joao A.C. Lima Joseph A. Delaney Matthew J. Feinstein Sanjiv J. Shah Russel P. Tracy Bruce M. Psaty |
| author_facet | Arjun Sinha Adovich S. Rivera Margaret F. Doyle Colleen Sitlani Alison Fohner Sally A. Huber Nels C. Olson Joao A.C. Lima Joseph A. Delaney Matthew J. Feinstein Sanjiv J. Shah Russel P. Tracy Bruce M. Psaty |
| author_sort | Arjun Sinha |
| collection | DOAJ |
| description | Background Immunomodulatory therapy may help prevent heart failure (HF). Data on immune cells and myocardial remodeling in older adults with cardiovascular risk factors are limited.Methods In the Multi-Ethnic Study of Atherosclerosis cohort, 869 adults had 19 peripheral immune cell subsets measured and underwent cardiac MRI during the baseline exam, of which 321 had assessment of left ventricular global circumferential strain (LV-GCS). We used linear regression with adjustment for demographics, cardiovascular risk factors, and cytomegalovirus serostatus to evaluate the cross-sectional association of immune cell subsets with left ventricular mass index (LVMI) and LV-GCS.Results The average age of the cohort was 61.6 ± 10.0 years and 53% were women. Higher proportions of γ/δ T cells were associated with lower absolute (worse) LV-GCS (–0.105% [95% CI –0.164%, –0.046%] per 1 SD higher proportion of γ/δ T cells, P = 0.0006). This association remained significant after Bonferroni’s correction. Higher proportions of classical monocytes were associated with worse absolute LV-GCS (–0.04% [95% CI –0.07%, 0.00%] per 1 SD higher proportion of classical monocytes, P = 0.04). This did not meet significance after Bonferroni’s correction. There were no other significant associations with LV-GCS or LVMI.Conclusion Pathways associated with γ/δ T cells may be potential targets for immunomodulatory therapy targeted at HF prevention in populations at risk.Funding Contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 and grant R01 HL98077 from the National Heart, Lung, and Blood Institute/NIH and grants KL2TR001424, UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences/NIH. |
| first_indexed | 2024-12-12T12:12:19Z |
| format | Article |
| id | doaj.art-2a226ac0223a4414b4f02b4ffb419e11 |
| institution | Directory Open Access Journal |
| issn | 2379-3708 |
| language | English |
| last_indexed | 2024-12-12T12:12:19Z |
| publishDate | 2021-07-01 |
| publisher | American Society for Clinical investigation |
| record_format | Article |
| series | JCI Insight |
| spelling | doaj.art-2a226ac0223a4414b4f02b4ffb419e112022-12-22T00:24:51ZengAmerican Society for Clinical investigationJCI Insight2379-37082021-07-01613Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of AtherosclerosisArjun SinhaAdovich S. RiveraMargaret F. DoyleColleen SitlaniAlison FohnerSally A. HuberNels C. OlsonJoao A.C. LimaJoseph A. DelaneyMatthew J. FeinsteinSanjiv J. ShahRussel P. TracyBruce M. PsatyBackground Immunomodulatory therapy may help prevent heart failure (HF). Data on immune cells and myocardial remodeling in older adults with cardiovascular risk factors are limited.Methods In the Multi-Ethnic Study of Atherosclerosis cohort, 869 adults had 19 peripheral immune cell subsets measured and underwent cardiac MRI during the baseline exam, of which 321 had assessment of left ventricular global circumferential strain (LV-GCS). We used linear regression with adjustment for demographics, cardiovascular risk factors, and cytomegalovirus serostatus to evaluate the cross-sectional association of immune cell subsets with left ventricular mass index (LVMI) and LV-GCS.Results The average age of the cohort was 61.6 ± 10.0 years and 53% were women. Higher proportions of γ/δ T cells were associated with lower absolute (worse) LV-GCS (–0.105% [95% CI –0.164%, –0.046%] per 1 SD higher proportion of γ/δ T cells, P = 0.0006). This association remained significant after Bonferroni’s correction. Higher proportions of classical monocytes were associated with worse absolute LV-GCS (–0.04% [95% CI –0.07%, 0.00%] per 1 SD higher proportion of classical monocytes, P = 0.04). This did not meet significance after Bonferroni’s correction. There were no other significant associations with LV-GCS or LVMI.Conclusion Pathways associated with γ/δ T cells may be potential targets for immunomodulatory therapy targeted at HF prevention in populations at risk.Funding Contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 and grant R01 HL98077 from the National Heart, Lung, and Blood Institute/NIH and grants KL2TR001424, UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences/NIH.https://doi.org/10.1172/jci.insight.149193CardiologyImmunology |
| spellingShingle | Arjun Sinha Adovich S. Rivera Margaret F. Doyle Colleen Sitlani Alison Fohner Sally A. Huber Nels C. Olson Joao A.C. Lima Joseph A. Delaney Matthew J. Feinstein Sanjiv J. Shah Russel P. Tracy Bruce M. Psaty Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis JCI Insight Cardiology Immunology |
| title | Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis |
| title_full | Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis |
| title_fullStr | Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis |
| title_full_unstemmed | Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis |
| title_short | Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis |
| title_sort | association of immune cell subsets with cardiac mechanics in the multi ethnic study of atherosclerosis |
| topic | Cardiology Immunology |
| url | https://doi.org/10.1172/jci.insight.149193 |
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