Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora

Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora

ObjectivesThis study aimed to investigate the protective effect of ginsenoside Rg3 (GRg3) against acute radiation proctitis (ARP) in rats.MethodsWistar rats were randomly divided into control, model, dexamethasone-positive, GRg3 low-dose, GRg3 medium-dose, and GRg3 high-dose groups. The ARP rat mode...

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Bibliographic Details
Main Authors: Xiaoyu Duan, Hongyi Cai, Tingting Hu, Lili Lin, Lu Zeng, Huixia Wang, Lei Cao, Xuxia Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
TLR4/MyD88/NF-κB signal pathway
ginsenoside Rg3
acute radiation proctitis
intestinal microflora
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1028576/full

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