A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers
Abstract Detection of biomarkers associated with body conditions provides in‐depth healthcare information and benefits to disease management, where the key challenge is to develop a minimally invasive platform with the ability to directly detect multiple biomarkers in body fluid. Dermal tattoo biose...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202103030 |
| _version_ | 1818968711819689984 |
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| author | Rongyan He Hao Liu Tianshu Fang Yan Niu Huiqing Zhang Fei Han Bin Gao Fei Li Feng Xu |
| author_facet | Rongyan He Hao Liu Tianshu Fang Yan Niu Huiqing Zhang Fei Han Bin Gao Fei Li Feng Xu |
| author_sort | Rongyan He |
| collection | DOAJ |
| description | Abstract Detection of biomarkers associated with body conditions provides in‐depth healthcare information and benefits to disease management, where the key challenge is to develop a minimally invasive platform with the ability to directly detect multiple biomarkers in body fluid. Dermal tattoo biosensor holds the potential to simultaneously detect multiple health‐related biomarkers in skin interstitial fluid because of the features of minimal invasion, easy operation, and equipment‐free result reading. Herein, a colorimetric dermal tattoo biosensor fabricated by a four‐area segmented microneedle patch is developed for multiplexed detection of health‐related biomarkers. The biosensor exhibits color changes in response to the change of biomarker concentration (i.e., pH, glucose, uric acid, and temperature), which can be directly read by naked eyes or captured by a camera for semi‐quantitative measurement. It is demonstrated that the colorimetric dermal tattoo biosensor can simultaneously detect multiple biomarkers in vitro, ex vivo, and in vivo, and monitor the changes of the biomarker concentration for at least 4 days, showing its great potential for long‐term health monitoring. |
| first_indexed | 2024-12-20T14:09:02Z |
| format | Article |
| id | doaj.art-2a22d2a445944e4994031dbbbcf1f2ec |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-20T14:09:02Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-2a22d2a445944e4994031dbbbcf1f2ec2022-12-21T19:38:11ZengWileyAdvanced Science2198-38442021-12-01824n/an/a10.1002/advs.202103030A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related BiomarkersRongyan He0Hao Liu1Tianshu Fang2Yan Niu3Huiqing Zhang4Fei Han5Bin Gao6Fei Li7Feng Xu8The Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University School of Life Science and Technology Xi'an 710049 ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University School of Life Science and Technology Xi'an 710049 ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University School of Life Science and Technology Xi'an 710049 ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University School of Life Science and Technology Xi'an 710049 ChinaBioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University Xi'an 710049 ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University School of Life Science and Technology Xi'an 710049 ChinaDepartment of Endocrinology Tangdu Hospital Air Force Military Medical University Xi'an 710038 ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University School of Life Science and Technology Xi'an 710049 ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University School of Life Science and Technology Xi'an 710049 ChinaAbstract Detection of biomarkers associated with body conditions provides in‐depth healthcare information and benefits to disease management, where the key challenge is to develop a minimally invasive platform with the ability to directly detect multiple biomarkers in body fluid. Dermal tattoo biosensor holds the potential to simultaneously detect multiple health‐related biomarkers in skin interstitial fluid because of the features of minimal invasion, easy operation, and equipment‐free result reading. Herein, a colorimetric dermal tattoo biosensor fabricated by a four‐area segmented microneedle patch is developed for multiplexed detection of health‐related biomarkers. The biosensor exhibits color changes in response to the change of biomarker concentration (i.e., pH, glucose, uric acid, and temperature), which can be directly read by naked eyes or captured by a camera for semi‐quantitative measurement. It is demonstrated that the colorimetric dermal tattoo biosensor can simultaneously detect multiple biomarkers in vitro, ex vivo, and in vivo, and monitor the changes of the biomarker concentration for at least 4 days, showing its great potential for long‐term health monitoring.https://doi.org/10.1002/advs.202103030health monitoringmicroneedle patchpoint‐of‐care testingskin interstitial fluidwearable biosensors |
| spellingShingle | Rongyan He Hao Liu Tianshu Fang Yan Niu Huiqing Zhang Fei Han Bin Gao Fei Li Feng Xu A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers Advanced Science health monitoring microneedle patch point‐of‐care testing skin interstitial fluid wearable biosensors |
| title | A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers |
| title_full | A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers |
| title_fullStr | A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers |
| title_full_unstemmed | A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers |
| title_short | A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health‐Related Biomarkers |
| title_sort | colorimetric dermal tattoo biosensor fabricated by microneedle patch for multiplexed detection of health related biomarkers |
| topic | health monitoring microneedle patch point‐of‐care testing skin interstitial fluid wearable biosensors |
| url | https://doi.org/10.1002/advs.202103030 |
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