Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination
SARS-CoV-2 Omicron infections are common among individuals who are vaccinated or have recovered from prior variant infection, but few reports have immunologically assessed serial Omicron infections. We characterized SARS-CoV-2 humoral responses in an individual who acquired laboratory-confirmed Omic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.947021/full |
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| author | Hope R. Lapointe Francis Mwimanzi Peter K. Cheung Peter K. Cheung Yurou Sang Fatima Yaseen Rebecca Kalikawe Sneha Datwani Rachel Waterworth Gisele Umviligihozo Siobhan Ennis Landon Young Winnie Dong Don Kirkby Laura Burns Victor Leung Victor Leung Victor Leung Daniel T. Holmes Daniel T. Holmes Mari L. DeMarco Mari L. DeMarco Janet Simons Janet Simons Nancy Matic Nancy Matic Nancy Matic Julio S.G. Montaner Julio S.G. Montaner Chanson J. Brumme Chanson J. Brumme Natalie Prystajecky Natalie Prystajecky Masahiro Niikura Christopher F. Lowe Christopher F. Lowe Christopher F. Lowe Marc G. Romney Marc G. Romney Marc G. Romney Mark A. Brockman Mark A. Brockman Mark A. Brockman Zabrina L. Brumme Zabrina L. Brumme |
| author_facet | Hope R. Lapointe Francis Mwimanzi Peter K. Cheung Peter K. Cheung Yurou Sang Fatima Yaseen Rebecca Kalikawe Sneha Datwani Rachel Waterworth Gisele Umviligihozo Siobhan Ennis Landon Young Winnie Dong Don Kirkby Laura Burns Victor Leung Victor Leung Victor Leung Daniel T. Holmes Daniel T. Holmes Mari L. DeMarco Mari L. DeMarco Janet Simons Janet Simons Nancy Matic Nancy Matic Nancy Matic Julio S.G. Montaner Julio S.G. Montaner Chanson J. Brumme Chanson J. Brumme Natalie Prystajecky Natalie Prystajecky Masahiro Niikura Christopher F. Lowe Christopher F. Lowe Christopher F. Lowe Marc G. Romney Marc G. Romney Marc G. Romney Mark A. Brockman Mark A. Brockman Mark A. Brockman Zabrina L. Brumme Zabrina L. Brumme |
| author_sort | Hope R. Lapointe |
| collection | DOAJ |
| description | SARS-CoV-2 Omicron infections are common among individuals who are vaccinated or have recovered from prior variant infection, but few reports have immunologically assessed serial Omicron infections. We characterized SARS-CoV-2 humoral responses in an individual who acquired laboratory-confirmed Omicron BA.1.15 ten weeks after a third dose of BNT162b2, and BA.2 thirteen weeks later. Responses were compared to 124 COVID-19-naive vaccinees. One month post-second and -third vaccine doses, the participant’s wild-type and BA.1-specific IgG, ACE2-displacement and virus neutralization activities were average for a COVID-19-naive triple-vaccinated individual. BA.1 infection boosted the participant’s responses to the cohort ≥95th percentile, but even this strong “hybrid” immunity failed to protect against BA.2. Reinfection increased BA.1 and BA.2-specific responses only modestly. Though vaccines clearly protect against severe disease, results highlight the continued importance of maintaining additional protective measures to counteract the immune-evasive Omicron variant, particularly as vaccine-induced immune responses naturally decline over time. |
| first_indexed | 2024-04-12T18:33:45Z |
| format | Article |
| id | doaj.art-2a230b967aaf4881b88dbe6f3a4df5ec |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T18:33:45Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2a230b967aaf4881b88dbe6f3a4df5ec2022-12-22T03:20:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.947021947021Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccinationHope R. Lapointe0Francis Mwimanzi1Peter K. Cheung2Peter K. Cheung3Yurou Sang4Fatima Yaseen5Rebecca Kalikawe6Sneha Datwani7Rachel Waterworth8Gisele Umviligihozo9Siobhan Ennis10Landon Young11Winnie Dong12Don Kirkby13Laura Burns14Victor Leung15Victor Leung16Victor Leung17Daniel T. Holmes18Daniel T. Holmes19Mari L. DeMarco20Mari L. DeMarco21Janet Simons22Janet Simons23Nancy Matic24Nancy Matic25Nancy Matic26Julio S.G. Montaner27Julio S.G. Montaner28Chanson J. Brumme29Chanson J. Brumme30Natalie Prystajecky31Natalie Prystajecky32Masahiro Niikura33Christopher F. Lowe34Christopher F. Lowe35Christopher F. Lowe36Marc G. Romney37Marc G. Romney38Marc G. Romney39Mark A. Brockman40Mark A. Brockman41Mark A. Brockman42Zabrina L. Brumme43Zabrina L. Brumme44British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaDivision of Medical Microbiology and Virology, St. Paul’s Hospital, Vancouver, BC, CanadaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDivision of Medical Microbiology and Virology, St. Paul’s Hospital, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaDivision of Medical Microbiology and Virology, St. Paul’s Hospital, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaDepartment of Medicine, University of British Columbia, Vancouver, BC, CanadaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaDepartment of Medicine, University of British Columbia, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaBritish Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaDivision of Medical Microbiology and Virology, St. Paul’s Hospital, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaDivision of Medical Microbiology and Virology, St. Paul’s Hospital, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, CanadaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, CanadaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, CanadaSARS-CoV-2 Omicron infections are common among individuals who are vaccinated or have recovered from prior variant infection, but few reports have immunologically assessed serial Omicron infections. We characterized SARS-CoV-2 humoral responses in an individual who acquired laboratory-confirmed Omicron BA.1.15 ten weeks after a third dose of BNT162b2, and BA.2 thirteen weeks later. Responses were compared to 124 COVID-19-naive vaccinees. One month post-second and -third vaccine doses, the participant’s wild-type and BA.1-specific IgG, ACE2-displacement and virus neutralization activities were average for a COVID-19-naive triple-vaccinated individual. BA.1 infection boosted the participant’s responses to the cohort ≥95th percentile, but even this strong “hybrid” immunity failed to protect against BA.2. Reinfection increased BA.1 and BA.2-specific responses only modestly. Though vaccines clearly protect against severe disease, results highlight the continued importance of maintaining additional protective measures to counteract the immune-evasive Omicron variant, particularly as vaccine-induced immune responses naturally decline over time.https://www.frontiersin.org/articles/10.3389/fimmu.2022.947021/fullCOVID-19vaccineOmicron variantreinfectionhumoral immunity |
| spellingShingle | Hope R. Lapointe Francis Mwimanzi Peter K. Cheung Peter K. Cheung Yurou Sang Fatima Yaseen Rebecca Kalikawe Sneha Datwani Rachel Waterworth Gisele Umviligihozo Siobhan Ennis Landon Young Winnie Dong Don Kirkby Laura Burns Victor Leung Victor Leung Victor Leung Daniel T. Holmes Daniel T. Holmes Mari L. DeMarco Mari L. DeMarco Janet Simons Janet Simons Nancy Matic Nancy Matic Nancy Matic Julio S.G. Montaner Julio S.G. Montaner Chanson J. Brumme Chanson J. Brumme Natalie Prystajecky Natalie Prystajecky Masahiro Niikura Christopher F. Lowe Christopher F. Lowe Christopher F. Lowe Marc G. Romney Marc G. Romney Marc G. Romney Mark A. Brockman Mark A. Brockman Mark A. Brockman Zabrina L. Brumme Zabrina L. Brumme Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination Frontiers in Immunology COVID-19 vaccine Omicron variant reinfection humoral immunity |
| title | Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination |
| title_full | Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination |
| title_fullStr | Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination |
| title_full_unstemmed | Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination |
| title_short | Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination |
| title_sort | serial infection with sars cov 2 omicron ba 1 and ba 2 following three dose covid 19 vaccination |
| topic | COVID-19 vaccine Omicron variant reinfection humoral immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.947021/full |
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