| Summary: | <p>Abstract</p> <p>We have developed a new method of application of C<sub>60 </sub>to cultured cells that does not require water-solubilization techniques. Normal and malignant cells take-up C<sub>60 </sub>and the inherent photoluminescence of C<sub>60 </sub>is detected within multiple cell lines. Treatment of cells with up to 200 μg/ml (200 ppm) of C<sub>60 </sub>does not alter morphology, cytoskeletal organization, cell cycle dynamics nor does it inhibit cell proliferation. Our work shows that pristine C<sub>60 </sub>is non-toxic to the cells, and suggests that fullerene-based nanocarriers may be used for biomedical applications.</p>
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