Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro
Bone remodelling in a healthy body is in constant balance, maintaining an adaptive and robust skeletal system. In osteoporosis this balance is disrupted with the rates of osteoclastic bone resorption exceeding osteoblastic bone formation, resulting in lower bone mineral density. Rooibos tea, is a po...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619305407 |
| _version_ | 1818950168776540160 |
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| author | Travers Sagar Abe Kasonga Ulrike Baschant Martina Rauner Shaakirah Moosa Sumari Marais Marlena Kruger Magdalena Coetzee |
| author_facet | Travers Sagar Abe Kasonga Ulrike Baschant Martina Rauner Shaakirah Moosa Sumari Marais Marlena Kruger Magdalena Coetzee |
| author_sort | Travers Sagar |
| collection | DOAJ |
| description | Bone remodelling in a healthy body is in constant balance, maintaining an adaptive and robust skeletal system. In osteoporosis this balance is disrupted with the rates of osteoclastic bone resorption exceeding osteoblastic bone formation, resulting in lower bone mineral density. Rooibos tea, is a popular South African drink made from Aspalathus linearis leaves grown in the Western Cape. This tea is rich in phenolic compounds which have been widely investigated in recent years as a potential treatment for many ailments. In this study, aspalathin, a phenolic compound found exclusively in rooibos, increases osteoblast formation and function including increased osteoblast marker expression and mineralisation. In addition, aspalathin decreased differentiation and function of osteoclasts as well as reducing osteoclast formation in an osteoclast/osteoblast co-culture model. These results illustrate bone-protective effects of aspalathin in vitro through the reduction of osteoclast activity and promotion of osteoblast activity, with potential applications in the maintenance of bone density. |
| first_indexed | 2024-12-20T09:14:18Z |
| format | Article |
| id | doaj.art-2a252b75a33c4fb09d01cde28447cced |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T09:14:18Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-2a252b75a33c4fb09d01cde28447cced2022-12-21T19:45:28ZengElsevierJournal of Functional Foods1756-46462020-01-0164103616Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitroTravers Sagar0Abe Kasonga1Ulrike Baschant2Martina Rauner3Shaakirah Moosa4Sumari Marais5Marlena Kruger6Magdalena Coetzee7Department of Physiology, University of Pretoria, Pretoria 0001, South AfricaDepartment of Physiology, University of Pretoria, Pretoria 0001, South Africa; Corresponding author at: Department of Physiology, University of Pretoria, Private Bag X323, Arcadia 0007, Pretoria, South Africa.Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, 01307, GermanyDepartment of Medicine III & Center for Healthy Aging, Technische Universität Dresden, 01307, GermanyDepartment of Physiology, University of Pretoria, Pretoria 0001, South AfricaDepartment of Physiology, University of Pretoria, Pretoria 0001, South AfricaSchool of Food and Nutrition, Massey Institute of Food Science and Technology, Massey University, Palmerston North 4442, New Zealand; Institute for Food, Nutrition and Well-being, University of Pretoria, Pretoria 0001, South Africa; Department of Human Nutrition, University of Pretoria, Pretoria, South AfricaDepartment of Physiology, University of Pretoria, Pretoria 0001, South Africa; Institute for Food, Nutrition and Well-being, University of Pretoria, Pretoria 0001, South AfricaBone remodelling in a healthy body is in constant balance, maintaining an adaptive and robust skeletal system. In osteoporosis this balance is disrupted with the rates of osteoclastic bone resorption exceeding osteoblastic bone formation, resulting in lower bone mineral density. Rooibos tea, is a popular South African drink made from Aspalathus linearis leaves grown in the Western Cape. This tea is rich in phenolic compounds which have been widely investigated in recent years as a potential treatment for many ailments. In this study, aspalathin, a phenolic compound found exclusively in rooibos, increases osteoblast formation and function including increased osteoblast marker expression and mineralisation. In addition, aspalathin decreased differentiation and function of osteoclasts as well as reducing osteoclast formation in an osteoclast/osteoblast co-culture model. These results illustrate bone-protective effects of aspalathin in vitro through the reduction of osteoclast activity and promotion of osteoblast activity, with potential applications in the maintenance of bone density.http://www.sciencedirect.com/science/article/pii/S1756464619305407OsteoporosisAspalathinRooibosOsteoclastOsteoblastBone remodelling |
| spellingShingle | Travers Sagar Abe Kasonga Ulrike Baschant Martina Rauner Shaakirah Moosa Sumari Marais Marlena Kruger Magdalena Coetzee Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro Journal of Functional Foods Osteoporosis Aspalathin Rooibos Osteoclast Osteoblast Bone remodelling |
| title | Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro |
| title_full | Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro |
| title_fullStr | Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro |
| title_full_unstemmed | Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro |
| title_short | Aspalathin from Aspalathus linearis (rooibos) reduces osteoclast activity and increases osteoblast activity in vitro |
| title_sort | aspalathin from aspalathus linearis rooibos reduces osteoclast activity and increases osteoblast activity in vitro |
| topic | Osteoporosis Aspalathin Rooibos Osteoclast Osteoblast Bone remodelling |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619305407 |
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