The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis
The effect of Roncoleukin on the recovery of the bone tissue in plastic operational defects (autobone+OsteoSet-T) on the model of experimental tuberculous osteites in 36 rabbits caused by drug resistant clinical strains of M. tuberculosis was studied. It was conducted a comparative analysis of the r...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Vreden Russian Research Institute of Traumatology and Orthopedics
2013-09-01
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| Series: | Travmatologiâ i Ortopediâ Rossii |
| Subjects: | |
| Online Access: | https://journal.rniito.org/jour/article/view/358 |
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| author | M. L. Vitovskaya N. V. Zabolotnykh T. I. Vinogradova S. N. Vasilyeva A. S. Kaftyrev B. M. Ariel E. S. Kirillova T. A. Novitskaya S. V. Iskrovskiy M. S. Serdobintsev |
| author_facet | M. L. Vitovskaya N. V. Zabolotnykh T. I. Vinogradova S. N. Vasilyeva A. S. Kaftyrev B. M. Ariel E. S. Kirillova T. A. Novitskaya S. V. Iskrovskiy M. S. Serdobintsev |
| author_sort | M. L. Vitovskaya |
| collection | DOAJ |
| description | The effect of Roncoleukin on the recovery of the bone tissue in plastic operational defects (autobone+OsteoSet-T) on the model of experimental tuberculous osteites in 36 rabbits caused by drug resistant clinical strains of M. tuberculosis was studied. It was conducted a comparative analysis of the results of applying of Roncoleukin (12,5 mg/kg, 5 injections, one every 3 days) with anti-tuberculosis treatment in pre-and post-operative period. Efficacy was assessed in 1 and 6 months of surgical intervention on the phagocytic activity of peritoneal macrophages, X-ray study of plastics area, histological study of bone tissue sections. It was found that the most effective use of Roncoleukin appeared in the postoperative period. The analysis showed that Roncoleukin helped to accelerate the restructuring of plastic material - OsteoSet-T, reducing the prevalence of specific foci of inflammation in the bone tissue and the disappearance of alternative necrotic component; the increase of osteogenesis intensity with the new bone beams formation., as well as the activation of hematopoesis in bone marrow. The intensification of reparative processes in the bone combined with a distinct activation of phagocytosis. |
| first_indexed | 2024-12-19T20:52:51Z |
| format | Article |
| id | doaj.art-2a257be8978e4ce3a5a5a20cc100453b |
| institution | Directory Open Access Journal |
| issn | 2311-2905 2542-0933 |
| language | Russian |
| last_indexed | 2024-12-19T20:52:51Z |
| publishDate | 2013-09-01 |
| publisher | Vreden Russian Research Institute of Traumatology and Orthopedics |
| record_format | Article |
| series | Travmatologiâ i Ortopediâ Rossii |
| spelling | doaj.art-2a257be8978e4ce3a5a5a20cc100453b2022-12-21T20:06:03ZrusVreden Russian Research Institute of Traumatology and OrthopedicsTravmatologiâ i Ortopediâ Rossii2311-29052542-09332013-09-0103808710.21823/2311-2905-2013--3-80-87352The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitisM. L. Vitovskaya0N. V. Zabolotnykh1T. I. Vinogradova2S. N. Vasilyeva3A. S. Kaftyrev4B. M. Ariel5E. S. Kirillova6T. A. Novitskaya7S. V. Iskrovskiy8M. S. Serdobintsev9Saint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologySaint-Petersburg Research Institute of PhthisiopuimonologyThe effect of Roncoleukin on the recovery of the bone tissue in plastic operational defects (autobone+OsteoSet-T) on the model of experimental tuberculous osteites in 36 rabbits caused by drug resistant clinical strains of M. tuberculosis was studied. It was conducted a comparative analysis of the results of applying of Roncoleukin (12,5 mg/kg, 5 injections, one every 3 days) with anti-tuberculosis treatment in pre-and post-operative period. Efficacy was assessed in 1 and 6 months of surgical intervention on the phagocytic activity of peritoneal macrophages, X-ray study of plastics area, histological study of bone tissue sections. It was found that the most effective use of Roncoleukin appeared in the postoperative period. The analysis showed that Roncoleukin helped to accelerate the restructuring of plastic material - OsteoSet-T, reducing the prevalence of specific foci of inflammation in the bone tissue and the disappearance of alternative necrotic component; the increase of osteogenesis intensity with the new bone beams formation., as well as the activation of hematopoesis in bone marrow. The intensification of reparative processes in the bone combined with a distinct activation of phagocytosis.https://journal.rniito.org/jour/article/view/358экспериментальный туберкулезный оститнекрэктомияпластика дефектаронколейкинперитонеальные макрофагирепаративный остеогенезexperimental tuberculous osteitisnecrectomyplastic defectroncoleukinperitoneal macrophagesreparative osteogenesis |
| spellingShingle | M. L. Vitovskaya N. V. Zabolotnykh T. I. Vinogradova S. N. Vasilyeva A. S. Kaftyrev B. M. Ariel E. S. Kirillova T. A. Novitskaya S. V. Iskrovskiy M. S. Serdobintsev The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis Travmatologiâ i Ortopediâ Rossii экспериментальный туберкулезный остит некрэктомия пластика дефекта ронколейкин перитонеальные макрофаги репаративный остеогенез experimental tuberculous osteitis necrectomy plastic defect roncoleukin peritoneal macrophages reparative osteogenesis |
| title | The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis |
| title_full | The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis |
| title_fullStr | The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis |
| title_full_unstemmed | The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis |
| title_short | The influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis |
| title_sort | influence of roncoleukin on reparative processes of bone tissue in experimental tuberculous osteitis |
| topic | экспериментальный туберкулезный остит некрэктомия пластика дефекта ронколейкин перитонеальные макрофаги репаративный остеогенез experimental tuberculous osteitis necrectomy plastic defect roncoleukin peritoneal macrophages reparative osteogenesis |
| url | https://journal.rniito.org/jour/article/view/358 |
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