Resting‐state default mode network connectivity in young individuals with Down syndrome
Abstract Background Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using resting‐state fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure and density of the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1905 |
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| author | María Dolores Figueroa‐Jimenez Cristina Cañete‐Massé María Carbó‐Carreté Daniel Zarabozo‐Hurtado Maribel Peró‐Cebollero José Guadalupe Salazar‐Estrada Joan Guàrdia‐Olmos |
| author_facet | María Dolores Figueroa‐Jimenez Cristina Cañete‐Massé María Carbó‐Carreté Daniel Zarabozo‐Hurtado Maribel Peró‐Cebollero José Guadalupe Salazar‐Estrada Joan Guàrdia‐Olmos |
| author_sort | María Dolores Figueroa‐Jimenez |
| collection | DOAJ |
| description | Abstract Background Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using resting‐state fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure and density of the default mode network (DMN). Although data on this issue have been reported in adult DS individuals (age: >45 years), the DMN properties in young DS individuals have not been studied. The aim of this study was to describe the density and structure of the DMN network from fMRI signals in young DS (age: <36 years). Method A sample of 22 young people with DS between the ages of 16 and 35 (M = 25.5 and SD = 5.1) was recruited in various centers for people with intellectual disability (ID). In addition to sociodemographic data, a six‐minute fMRI session was recorded with a 3. T Philips Ingenia scanner. A control group of 22 young people, matched by age and gender, was obtained from the Human Connectome Project (to compare the networks properties between groups). Results The values of the 48 ROIs that configured the DMN were obtained, and the connectivity graphs for each subject, the average connectivity graph for each group, the clustering and degree values for each ROI, and the average functional connectivity network were estimated. Conclusions A higher density of overactivation was identified in DS group in the ventral, sensorimotor, and visual DMN networks, although within a framework of a wide variability of connectivity patterns in comparison with the control group network. These results extend our understanding of the functional connectivity networks pattern and intrasubject variability in DS. |
| first_indexed | 2024-12-17T13:51:46Z |
| format | Article |
| id | doaj.art-2a259672a5a741cd85f32fa8b0d4f39c |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-17T13:51:46Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-2a259672a5a741cd85f32fa8b0d4f39c2022-12-21T21:46:02ZengWileyBrain and Behavior2162-32792021-01-01111n/an/a10.1002/brb3.1905Resting‐state default mode network connectivity in young individuals with Down syndromeMaría Dolores Figueroa‐Jimenez0Cristina Cañete‐Massé1María Carbó‐Carreté2Daniel Zarabozo‐Hurtado3Maribel Peró‐Cebollero4José Guadalupe Salazar‐Estrada5Joan Guàrdia‐Olmos6Department of Health Sciences Centro Universitario de los Valles University of Guadalajara Guadalajara MexicoDepartment of Social Psychology & Quantitative Psychology Faculty of Psychology University of Barcelona Barcelona SpainInstitute of Neuroscience University of Barcelona Barcelona SpainRIO Group Clinical Laboratory Center for Research in Advanced Functional Neuro‐Diagnosis CINDFA Guadalajara MéxicoDepartment of Social Psychology & Quantitative Psychology Faculty of Psychology University of Barcelona Barcelona SpainDepartment of Health Sciences Centro Universitario de los Valles University of Guadalajara Guadalajara MexicoDepartment of Social Psychology & Quantitative Psychology Faculty of Psychology University of Barcelona Barcelona SpainAbstract Background Down syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using resting‐state fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure and density of the default mode network (DMN). Although data on this issue have been reported in adult DS individuals (age: >45 years), the DMN properties in young DS individuals have not been studied. The aim of this study was to describe the density and structure of the DMN network from fMRI signals in young DS (age: <36 years). Method A sample of 22 young people with DS between the ages of 16 and 35 (M = 25.5 and SD = 5.1) was recruited in various centers for people with intellectual disability (ID). In addition to sociodemographic data, a six‐minute fMRI session was recorded with a 3. T Philips Ingenia scanner. A control group of 22 young people, matched by age and gender, was obtained from the Human Connectome Project (to compare the networks properties between groups). Results The values of the 48 ROIs that configured the DMN were obtained, and the connectivity graphs for each subject, the average connectivity graph for each group, the clustering and degree values for each ROI, and the average functional connectivity network were estimated. Conclusions A higher density of overactivation was identified in DS group in the ventral, sensorimotor, and visual DMN networks, although within a framework of a wide variability of connectivity patterns in comparison with the control group network. These results extend our understanding of the functional connectivity networks pattern and intrasubject variability in DS.https://doi.org/10.1002/brb3.1905connectivity graphsdefault mode networkDown syndromefMRIfunctional connectivityintellectual disability |
| spellingShingle | María Dolores Figueroa‐Jimenez Cristina Cañete‐Massé María Carbó‐Carreté Daniel Zarabozo‐Hurtado Maribel Peró‐Cebollero José Guadalupe Salazar‐Estrada Joan Guàrdia‐Olmos Resting‐state default mode network connectivity in young individuals with Down syndrome Brain and Behavior connectivity graphs default mode network Down syndrome fMRI functional connectivity intellectual disability |
| title | Resting‐state default mode network connectivity in young individuals with Down syndrome |
| title_full | Resting‐state default mode network connectivity in young individuals with Down syndrome |
| title_fullStr | Resting‐state default mode network connectivity in young individuals with Down syndrome |
| title_full_unstemmed | Resting‐state default mode network connectivity in young individuals with Down syndrome |
| title_short | Resting‐state default mode network connectivity in young individuals with Down syndrome |
| title_sort | resting state default mode network connectivity in young individuals with down syndrome |
| topic | connectivity graphs default mode network Down syndrome fMRI functional connectivity intellectual disability |
| url | https://doi.org/10.1002/brb3.1905 |
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