Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
The clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked to the release of anti-inflammatory cytokines...
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MDPI AG
2021-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/11/1141 |
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| author | Minjoo Han Gyoungah Ryu Seong-Ah Shin Jangeun An Huiji Kim Daeho Park Dae-Hee Lee Chang Sup Lee |
| author_facet | Minjoo Han Gyoungah Ryu Seong-Ah Shin Jangeun An Huiji Kim Daeho Park Dae-Hee Lee Chang Sup Lee |
| author_sort | Minjoo Han |
| collection | DOAJ |
| description | The clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked to the release of anti-inflammatory cytokines to eliminate inflammatory responses. Defective clearance of apoptotic cells can cause severe inflammation and autoimmune responses due to secondary necrosis of apoptotic cells. Recently accumulated evidence indicates that apoptotic cells and their clearance have important physiological roles in addition to immune-related functions. Herein, we review the current understanding of the mechanisms and fundamental roles of apoptotic cell clearance and the beneficial roles of apoptotic cells in physiological processes such as differentiation and development. |
| first_indexed | 2024-03-10T05:20:29Z |
| format | Article |
| id | doaj.art-2a25e3e33ba34f02a2a00f6e7a9c260d |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T05:20:29Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-2a25e3e33ba34f02a2a00f6e7a9c260d2023-11-23T00:03:25ZengMDPI AGLife2075-17292021-10-011111114110.3390/life11111141Physiological Roles of Apoptotic Cell Clearance: Beyond Immune FunctionsMinjoo Han0Gyoungah Ryu1Seong-Ah Shin2Jangeun An3Huiji Kim4Daeho Park5Dae-Hee Lee6Chang Sup Lee7College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaSchool of Life Sciences and Aging Research Institute, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung 25456, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, KoreaThe clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked to the release of anti-inflammatory cytokines to eliminate inflammatory responses. Defective clearance of apoptotic cells can cause severe inflammation and autoimmune responses due to secondary necrosis of apoptotic cells. Recently accumulated evidence indicates that apoptotic cells and their clearance have important physiological roles in addition to immune-related functions. Herein, we review the current understanding of the mechanisms and fundamental roles of apoptotic cell clearance and the beneficial roles of apoptotic cells in physiological processes such as differentiation and development.https://www.mdpi.com/2075-1729/11/11/1141apoptosisapoptotic cell clearancedifferentiationdevelopmentinflammationphagocyte |
| spellingShingle | Minjoo Han Gyoungah Ryu Seong-Ah Shin Jangeun An Huiji Kim Daeho Park Dae-Hee Lee Chang Sup Lee Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions Life apoptosis apoptotic cell clearance differentiation development inflammation phagocyte |
| title | Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions |
| title_full | Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions |
| title_fullStr | Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions |
| title_full_unstemmed | Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions |
| title_short | Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions |
| title_sort | physiological roles of apoptotic cell clearance beyond immune functions |
| topic | apoptosis apoptotic cell clearance differentiation development inflammation phagocyte |
| url | https://www.mdpi.com/2075-1729/11/11/1141 |
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