Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis
The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signal...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03764-1 |
| _version_ | 1818343302048514048 |
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| author | Karim C. El Kasmi Padade M. Vue Aimee L. Anderson Michael W. Devereaux Swati Ghosh Natarajan Balasubramaniyan Sophie A. Fillon Carola Dahrenmoeller Ayed Allawzi Crystal Woods Sarah McKenna Clyde J. Wright Linda Johnson Angelo D’Alessandro Julie A. Reisz Eva Nozik-Grayck Frederick J. Suchy Ronald J. Sokol |
| author_facet | Karim C. El Kasmi Padade M. Vue Aimee L. Anderson Michael W. Devereaux Swati Ghosh Natarajan Balasubramaniyan Sophie A. Fillon Carola Dahrenmoeller Ayed Allawzi Crystal Woods Sarah McKenna Clyde J. Wright Linda Johnson Angelo D’Alessandro Julie A. Reisz Eva Nozik-Grayck Frederick J. Suchy Ronald J. Sokol |
| author_sort | Karim C. El Kasmi |
| collection | DOAJ |
| description | The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signaling. |
| first_indexed | 2024-12-13T16:28:25Z |
| format | Article |
| id | doaj.art-2a266070415e43ab8b818dd620dfebf5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:28:25Z |
| publishDate | 2018-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2a266070415e43ab8b818dd620dfebf52022-12-21T23:38:33ZengNature PortfolioNature Communications2041-17232018-04-019111410.1038/s41467-018-03764-1Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasisKarim C. El Kasmi0Padade M. Vue1Aimee L. Anderson2Michael W. Devereaux3Swati Ghosh4Natarajan Balasubramaniyan5Sophie A. Fillon6Carola Dahrenmoeller7Ayed Allawzi8Crystal Woods9Sarah McKenna10Clyde J. Wright11Linda Johnson12Angelo D’Alessandro13Julie A. Reisz14Eva Nozik-Grayck15Frederick J. Suchy16Ronald J. Sokol17Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineCardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineSection of Neonatology, Department of Pediatrics, University of Colorado School of MedicineSection of Neonatology, Department of Pediatrics, University of Colorado School of MedicineDepartment of Pathology, University of Colorado School of MedicineCardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of MedicineCardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of MedicineCardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineDepartment of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of MedicineThe authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signaling.https://doi.org/10.1038/s41467-018-03764-1 |
| spellingShingle | Karim C. El Kasmi Padade M. Vue Aimee L. Anderson Michael W. Devereaux Swati Ghosh Natarajan Balasubramaniyan Sophie A. Fillon Carola Dahrenmoeller Ayed Allawzi Crystal Woods Sarah McKenna Clyde J. Wright Linda Johnson Angelo D’Alessandro Julie A. Reisz Eva Nozik-Grayck Frederick J. Suchy Ronald J. Sokol Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis Nature Communications |
| title | Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_full | Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_fullStr | Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_full_unstemmed | Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_short | Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_sort | macrophage derived il 1β nf κb signaling mediates parenteral nutrition associated cholestasis |
| url | https://doi.org/10.1038/s41467-018-03764-1 |
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