Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signal...

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Bibliographic Details
Main Authors: Karim C. El Kasmi, Padade M. Vue, Aimee L. Anderson, Michael W. Devereaux, Swati Ghosh, Natarajan Balasubramaniyan, Sophie A. Fillon, Carola Dahrenmoeller, Ayed Allawzi, Crystal Woods, Sarah McKenna, Clyde J. Wright, Linda Johnson, Angelo D’Alessandro, Julie A. Reisz, Eva Nozik-Grayck, Frederick J. Suchy, Ronald J. Sokol
Format: Article
Language:English
Published: Nature Portfolio 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03764-1

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