Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances
Background: Per- and polyfluoroalkyl substances (PFASs) are a growing public health concern. Some longer chain PFASs bioaccumulate and many compounds persist in the environment for long time periods. Recent studies have established their ability to pass through placenta, yet data on the transplacent...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019305161 |
| _version_ | 1818363296352305152 |
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| author | Berrak Eryasa Philippe Grandjean Flemming Nielsen Damaskini Valvi Denis Zmirou-Navier Elsie Sunderland Pal Weihe Youssef Oulhote |
| author_facet | Berrak Eryasa Philippe Grandjean Flemming Nielsen Damaskini Valvi Denis Zmirou-Navier Elsie Sunderland Pal Weihe Youssef Oulhote |
| author_sort | Berrak Eryasa |
| collection | DOAJ |
| description | Background: Per- and polyfluoroalkyl substances (PFASs) are a growing public health concern. Some longer chain PFASs bioaccumulate and many compounds persist in the environment for long time periods. Recent studies have established their ability to pass through placenta, yet data on the transplacental transfer efficiency and partitioning of short and long chain PFASs in blood matrices are limited. Objectives: To assess predictors of the partitioning of 17 PFAS compounds detected in the maternal serum, umbilical cord serum and whole cord blood samples from matched mother-newborn pairs from two Faroe Islands cohorts. Methods: We examined 151 mother-newborn pairs from two successive Faroese birth cohorts. Cord:maternal serum (transplacental transfer) and serum:whole cord blood (blood partitioning) ratios were estimated for 17 PFAS compounds. We also examined the relationships of these ratios with maternal, newborns', and physico-chemical properties using multivariable regression analyses. Results: Moderate to high correlations were observed between maternal and cord serum PFAS concentrations (ρ: 0.41 to 0.95), indicating significant transfer of these compounds from the mother to the fetus. Median transplacental transfer ratios were generally below 1, except for perfluorooctane sulfonamide (FOSA), and ranged between 0.36 for perfluorodecanoate (PFDA) and perfluoroundecanoate (PFUnDA) and 1.21 for FOSA. Most PFASs exhibited a preference to the serum component of the blood, except FOSA and perfluoroheptanoate (PFHpA), with blood partitioning ratios ranging from 0.36 for FOSA to 2.75 for PFUnDA. Both the functional groups and carbon chain length of different PFASs were important predictors of transplacental transfer and blood partitioning. We observed a U-shaped relationship between transplacental transfer ratios and carbon chain length for perfluorocarboxylates and perfluorosulfonates. Importantly, gestational diabetes was also a strong predictor of transplacental transfer ratios, with significantly higher transfer in mothers with gestational diabetes. Conclusions: Our findings provide a better understanding of the transplacental transfer and blood partitioning of a large number of PFAS compounds. Results elucidate the importance of chemical structure for future risk assessments and choice of appropriate blood matrices for measurement of PFAS compounds. |
| first_indexed | 2024-12-13T21:46:13Z |
| format | Article |
| id | doaj.art-2a26f409a9854718b7c0faa208343c35 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-13T21:46:13Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-2a26f409a9854718b7c0faa208343c352022-12-21T23:30:25ZengElsevierEnvironment International0160-41202019-09-01130Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substancesBerrak Eryasa0Philippe Grandjean1Flemming Nielsen2Damaskini Valvi3Denis Zmirou-Navier4Elsie Sunderland5Pal Weihe6Youssef Oulhote7Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States of America; EHESP-School of Public Health, Sorbonne Paris Cité, Rennes, FranceDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States of America; University of Southern Denmark, Odense, DenmarkUniversity of Southern Denmark, Odense, DenmarkDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States of AmericaEHESP-School of Public Health, Sorbonne Paris Cité, Rennes, FranceDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States of America; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, United States of AmericaThe Faroese Hospital System, Tórshavn, Faroe IslandsDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States of America; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, Amherst, MA, United States of America; Corresponding author at: Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, 432 Arnold House, Amherst, MA 01003, United States of America.Background: Per- and polyfluoroalkyl substances (PFASs) are a growing public health concern. Some longer chain PFASs bioaccumulate and many compounds persist in the environment for long time periods. Recent studies have established their ability to pass through placenta, yet data on the transplacental transfer efficiency and partitioning of short and long chain PFASs in blood matrices are limited. Objectives: To assess predictors of the partitioning of 17 PFAS compounds detected in the maternal serum, umbilical cord serum and whole cord blood samples from matched mother-newborn pairs from two Faroe Islands cohorts. Methods: We examined 151 mother-newborn pairs from two successive Faroese birth cohorts. Cord:maternal serum (transplacental transfer) and serum:whole cord blood (blood partitioning) ratios were estimated for 17 PFAS compounds. We also examined the relationships of these ratios with maternal, newborns', and physico-chemical properties using multivariable regression analyses. Results: Moderate to high correlations were observed between maternal and cord serum PFAS concentrations (ρ: 0.41 to 0.95), indicating significant transfer of these compounds from the mother to the fetus. Median transplacental transfer ratios were generally below 1, except for perfluorooctane sulfonamide (FOSA), and ranged between 0.36 for perfluorodecanoate (PFDA) and perfluoroundecanoate (PFUnDA) and 1.21 for FOSA. Most PFASs exhibited a preference to the serum component of the blood, except FOSA and perfluoroheptanoate (PFHpA), with blood partitioning ratios ranging from 0.36 for FOSA to 2.75 for PFUnDA. Both the functional groups and carbon chain length of different PFASs were important predictors of transplacental transfer and blood partitioning. We observed a U-shaped relationship between transplacental transfer ratios and carbon chain length for perfluorocarboxylates and perfluorosulfonates. Importantly, gestational diabetes was also a strong predictor of transplacental transfer ratios, with significantly higher transfer in mothers with gestational diabetes. Conclusions: Our findings provide a better understanding of the transplacental transfer and blood partitioning of a large number of PFAS compounds. Results elucidate the importance of chemical structure for future risk assessments and choice of appropriate blood matrices for measurement of PFAS compounds.http://www.sciencedirect.com/science/article/pii/S0160412019305161 |
| spellingShingle | Berrak Eryasa Philippe Grandjean Flemming Nielsen Damaskini Valvi Denis Zmirou-Navier Elsie Sunderland Pal Weihe Youssef Oulhote Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances Environment International |
| title | Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances |
| title_full | Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances |
| title_fullStr | Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances |
| title_full_unstemmed | Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances |
| title_short | Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances |
| title_sort | physico chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019305161 |
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