The reference intervals for thyroid hormones: A four year investigation in Chinese population
IntroductionThe reference intervals (RIs) are of great importance for physicans to determine whether or not an individual is healthy. However, many clinical laboratories in China still adopted the default RI provided by the manufacturers; and these “uncalibrated” RIs might lead to the misdiagnosis o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1046381/full |
| _version_ | 1828070443811078144 |
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| author | Tiancheng Xie Mingchuan Su Jie Feng Xiaoying Pan Chuan Wang Chuan Wang Tian Tang Tian Tang |
| author_facet | Tiancheng Xie Mingchuan Su Jie Feng Xiaoying Pan Chuan Wang Chuan Wang Tian Tang Tian Tang |
| author_sort | Tiancheng Xie |
| collection | DOAJ |
| description | IntroductionThe reference intervals (RIs) are of great importance for physicans to determine whether or not an individual is healthy. However, many clinical laboratories in China still adopted the default RI provided by the manufacturers; and these “uncalibrated” RIs might lead to the misdiagnosis of diseases. In the present study, we enroll reference people with the purpose of determining the RIs of serum triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in Chinese population, and explore the possible roles of age and sex on the levels of biomarkers.MethodsSerum samples from 66,609 individuals who met the inclusion criteria were analyzed using an Roche Cobas E 601 hormone analyzer. The dynamic trends of biomarker were visually assessed by their concentrations over age and sex. Specific partitions were determined by the method of Harris and Boyd. RIs, corresponding to the 2.5th and 97.5th percentiles, as well as the 0.5th, 25th, 50th, 75th and 99.5th percentiles were calculated for each reference partition using a non-parametric rank approach.ResultsThe serum level of T3, T4, FT4 or TSH showed a right-skewed distribution in both males and females while FT3 presented an approximate normal distribution. Females had a higher mode value of serum T3 or T4, but a lower mode value of serum TSH, FT3 or FT4. All five biomarkers did not need age partitioning according to the approach of harris and boyd, while T3 and FT3 need sex partitioning.ConclusionsThe present study not only determined the age- and sex-specific trends of the five thyroid hormones, but provided sex-stratified RIs for T3 and FT3, valuably contributing to the current literature and timely evaluation of thyroid health and disease. |
| first_indexed | 2024-04-11T00:37:48Z |
| format | Article |
| id | doaj.art-2a2735d1ffb444508b8c2ef8f04e9d77 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T00:37:48Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2a2735d1ffb444508b8c2ef8f04e9d772023-01-06T14:52:25ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10463811046381The reference intervals for thyroid hormones: A four year investigation in Chinese populationTiancheng Xie0Mingchuan Su1Jie Feng2Xiaoying Pan3Chuan Wang4Chuan Wang5Tian Tang6Tian Tang7West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, ChinaIntroductionThe reference intervals (RIs) are of great importance for physicans to determine whether or not an individual is healthy. However, many clinical laboratories in China still adopted the default RI provided by the manufacturers; and these “uncalibrated” RIs might lead to the misdiagnosis of diseases. In the present study, we enroll reference people with the purpose of determining the RIs of serum triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in Chinese population, and explore the possible roles of age and sex on the levels of biomarkers.MethodsSerum samples from 66,609 individuals who met the inclusion criteria were analyzed using an Roche Cobas E 601 hormone analyzer. The dynamic trends of biomarker were visually assessed by their concentrations over age and sex. Specific partitions were determined by the method of Harris and Boyd. RIs, corresponding to the 2.5th and 97.5th percentiles, as well as the 0.5th, 25th, 50th, 75th and 99.5th percentiles were calculated for each reference partition using a non-parametric rank approach.ResultsThe serum level of T3, T4, FT4 or TSH showed a right-skewed distribution in both males and females while FT3 presented an approximate normal distribution. Females had a higher mode value of serum T3 or T4, but a lower mode value of serum TSH, FT3 or FT4. All five biomarkers did not need age partitioning according to the approach of harris and boyd, while T3 and FT3 need sex partitioning.ConclusionsThe present study not only determined the age- and sex-specific trends of the five thyroid hormones, but provided sex-stratified RIs for T3 and FT3, valuably contributing to the current literature and timely evaluation of thyroid health and disease.https://www.frontiersin.org/articles/10.3389/fendo.2022.1046381/fullthyroid hormonesreference intervalsagesexChinese population |
| spellingShingle | Tiancheng Xie Mingchuan Su Jie Feng Xiaoying Pan Chuan Wang Chuan Wang Tian Tang Tian Tang The reference intervals for thyroid hormones: A four year investigation in Chinese population Frontiers in Endocrinology thyroid hormones reference intervals age sex Chinese population |
| title | The reference intervals for thyroid hormones: A four year investigation in Chinese population |
| title_full | The reference intervals for thyroid hormones: A four year investigation in Chinese population |
| title_fullStr | The reference intervals for thyroid hormones: A four year investigation in Chinese population |
| title_full_unstemmed | The reference intervals for thyroid hormones: A four year investigation in Chinese population |
| title_short | The reference intervals for thyroid hormones: A four year investigation in Chinese population |
| title_sort | reference intervals for thyroid hormones a four year investigation in chinese population |
| topic | thyroid hormones reference intervals age sex Chinese population |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1046381/full |
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