Entering an era of dynamic structural biology…
Abstract A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-018-0533-4 |
| _version_ | 1828199114091790336 |
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| author | Allen M. Orville |
| author_facet | Allen M. Orville |
| author_sort | Allen M. Orville |
| collection | DOAJ |
| description | Abstract A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and inactivation of the antibiotic ceftriaxone by a β-lactamase enzyme from Mycobacterium tuberculosis. Their work demonstrates the general applicability of time-resolved crystallography, from which dynamic structures, at atomic resolution, can be obtained. See research article: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0524-5. |
| first_indexed | 2024-04-12T10:49:46Z |
| format | Article |
| id | doaj.art-2a2746f46c2d4e5ab59636928ff38c68 |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-04-12T10:49:46Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-2a2746f46c2d4e5ab59636928ff38c682022-12-22T03:36:17ZengBMCBMC Biology1741-70072018-05-011611410.1186/s12915-018-0533-4Entering an era of dynamic structural biology…Allen M. Orville0Diamond Light Source, Research Complex at Harwell, and University of OxfordAbstract A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and inactivation of the antibiotic ceftriaxone by a β-lactamase enzyme from Mycobacterium tuberculosis. Their work demonstrates the general applicability of time-resolved crystallography, from which dynamic structures, at atomic resolution, can be obtained. See research article: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0524-5.http://link.springer.com/article/10.1186/s12915-018-0533-4 |
| spellingShingle | Allen M. Orville Entering an era of dynamic structural biology… BMC Biology |
| title | Entering an era of dynamic structural biology… |
| title_full | Entering an era of dynamic structural biology… |
| title_fullStr | Entering an era of dynamic structural biology… |
| title_full_unstemmed | Entering an era of dynamic structural biology… |
| title_short | Entering an era of dynamic structural biology… |
| title_sort | entering an era of dynamic structural biology |
| url | http://link.springer.com/article/10.1186/s12915-018-0533-4 |
| work_keys_str_mv | AT allenmorville enteringaneraofdynamicstructuralbiology |