Altered Profile of E1-S Transporters in Endometrial Cancer: Lower Protein Levels of ABCG2 and OSTβ and Up-Regulation of <i>SLCO1B3</i> Expression

Altered Profile of E1-S Transporters in Endometrial Cancer: Lower Protein Levels of ABCG2 and OSTβ and Up-Regulation of <i>SLCO1B3</i> Expression

Endometrial cancer (EC) is associated with increased estrogen actions. Locally, estrogens can be formed from estrone-sulphate (E1-S) after cellular uptake by organic anion-transporting polypeptides (OATP) or organic anion transporters (OAT). Efflux of E1-S is enabled by ATP Binding Cassette transpor...

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Bibliographic Details
Main Authors: Renata Pavlič, Suzana Vidic, Maja Anko, Tamara Knific, Tomaž Büdefeld, Kristina Marton, Maša Sinreih, Stefan Poschner, Walter Jäger, Snježana Frković-Grazio, Tea Lanišnik Rižner
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
estrone-sulphate (E1-S)
intracrinology
sulfatase pathway
E1-S transporters
ATP-binding cassette transporters
organic anion-transporting polypeptides
Online Access:https://www.mdpi.com/1422-0067/22/8/3819

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