Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat
Background and purpose: The present study aimed at exploring the effects of eight-week high intensity interval training (HIIT) program on gene expression factors involved in cholesterol reverse transport in liver tissue of ischemic rats. Materials and methods: In this study, 28 Wistar Rats (250 ±20...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2021-05-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-16190-en.html |
| _version_ | 1797943985203838976 |
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| author | Hesam Parsa Yaghoub Mehri Alvar Fahimeh Erfani Aadab |
| author_facet | Hesam Parsa Yaghoub Mehri Alvar Fahimeh Erfani Aadab |
| author_sort | Hesam Parsa |
| collection | DOAJ |
| description | Background and purpose: The present study aimed at exploring the effects of eight-week high intensity interval training (HIIT) program on gene expression factors involved in cholesterol reverse transport in liver tissue of ischemic rats.
Materials and methods: In this study, 28 Wistar Rats (250 ±20 g) were randomly divided into four groups: Ischemia (n=8), Placebo (n=8), Training (n=8), and Ischemia plus Training (n=8). Myocardial infarction was induced by ligation of left anterior descending coronary artery (LAD) for 30 minutes. High intensity interval training program (4 min of running at 85-90% VO2max and 2 min active recovery at 50-60% VO2max) was performed using treadmill for 8 weeks (three times a week /40 minutes).
Results: The expression levels of ABCG1 receptor gene and Apolipoprotein A1 significantly increased in high intensity interval training group compared to Ischemia group (P=0.008) and placebo group (P= 0.037). Also, the expression of Apolipoprotein 2 receptor gene showed significant increase in HIIT+ Ischemia group compared to Ischemia group (P=0.041) and placebo group (P=0.04). In addition, the expression of SR-BR receptor gene was found to increase in HIIT+ Ischemia group compared to the placebo group (P=0.028).
Conclusion: High intensity interval training in ischemic rats increases the key factors involved in reverse cholesterol transfer process and ultimately leads to an increase in HDL, which has a positive effect on prevention of atherosclerosis and ischemia. |
| first_indexed | 2024-04-10T20:32:35Z |
| format | Article |
| id | doaj.art-2a2981db27b24afba5b34ebca3e04cca |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:32:35Z |
| publishDate | 2021-05-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-2a2981db27b24afba5b34ebca3e04cca2023-01-25T05:13:23ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792021-05-01311961122Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic RatHesam Parsa0Yaghoub Mehri Alvar1Fahimeh Erfani Aadab2 Assistant Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Bu Ali Sina University, Hamadan, Iran PhD in Exercise Physiology, Faculty of Sport Sciences, Bu Ali Sina University ,Hamadan, Iran MSc in Exercise Physiology, Faculty of Sport Sciences, Bu Ali Sina University, Hamadan, Iran Background and purpose: The present study aimed at exploring the effects of eight-week high intensity interval training (HIIT) program on gene expression factors involved in cholesterol reverse transport in liver tissue of ischemic rats. Materials and methods: In this study, 28 Wistar Rats (250 ±20 g) were randomly divided into four groups: Ischemia (n=8), Placebo (n=8), Training (n=8), and Ischemia plus Training (n=8). Myocardial infarction was induced by ligation of left anterior descending coronary artery (LAD) for 30 minutes. High intensity interval training program (4 min of running at 85-90% VO2max and 2 min active recovery at 50-60% VO2max) was performed using treadmill for 8 weeks (three times a week /40 minutes). Results: The expression levels of ABCG1 receptor gene and Apolipoprotein A1 significantly increased in high intensity interval training group compared to Ischemia group (P=0.008) and placebo group (P= 0.037). Also, the expression of Apolipoprotein 2 receptor gene showed significant increase in HIIT+ Ischemia group compared to Ischemia group (P=0.041) and placebo group (P=0.04). In addition, the expression of SR-BR receptor gene was found to increase in HIIT+ Ischemia group compared to the placebo group (P=0.028). Conclusion: High intensity interval training in ischemic rats increases the key factors involved in reverse cholesterol transfer process and ultimately leads to an increase in HDL, which has a positive effect on prevention of atherosclerosis and ischemia.http://jmums.mazums.ac.ir/article-1-16190-en.htmlmyocardial ischemiacholesterol reverse transporthigh intensity interval trainingapolipoprotein |
| spellingShingle | Hesam Parsa Yaghoub Mehri Alvar Fahimeh Erfani Aadab Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat Journal of Mazandaran University of Medical Sciences myocardial ischemia cholesterol reverse transport high intensity interval training apolipoprotein |
| title | Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat |
| title_full | Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat |
| title_fullStr | Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat |
| title_full_unstemmed | Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat |
| title_short | Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat |
| title_sort | effects of eight weeks of high intensity interval training program on gene expression factors involved in cholesterol reverse transport in liver tissue of ischemic rat |
| topic | myocardial ischemia cholesterol reverse transport high intensity interval training apolipoprotein |
| url | http://jmums.mazums.ac.ir/article-1-16190-en.html |
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