Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity

Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity

Reverse transcriptase hTERT is essential to telomerase function in stem cells, as well as in 85–90% of human cancers. Its high expression in stem cells or cancer cells has made telomerase/hTERT an attractive therapeutic target for anti-aging and anti-tumor applications. In this study, we screened a...

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Bibliographic Details
Main Authors: Siyu Yan, Song Lin, Kexin Chen, Shanshan Yin, Haoyue Peng, Nanshuo Cai, Wenbin Ma, Zhou Songyang, Yan Huang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
telomerase/hTERT
anti-cancer
sanguinarine chloride
cellular senescence
Online Access:https://www.mdpi.com/2073-4409/11/9/1485

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