Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action
<i>Salvia miltiorrhiza</i> Bunge (<i>S. miltiorrhiza</i>) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea. Considering its extensive usage as a therapeutic agent for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/9/857 |
| _version_ | 1797553766314016768 |
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| author | Inyong Jung Hyerin Kim Seongcheol Moon Hyuk Lee Bonglee Kim |
| author_facet | Inyong Jung Hyerin Kim Seongcheol Moon Hyuk Lee Bonglee Kim |
| author_sort | Inyong Jung |
| collection | DOAJ |
| description | <i>Salvia miltiorrhiza</i> Bunge (<i>S. miltiorrhiza</i>) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of <i>S. miltiorrhiza</i>, including inflammation, fibrosis, oxidative stress, and apoptosis. The findings on multi-functional properties of <i>S. miltiorrhiza</i> discussed in this article support the efficacy of <i>S. miltiorrhiza</i> extract on various diseases, but also call for further research on the multiple mechanisms that mediate its therapeutic effects. |
| first_indexed | 2024-03-10T16:21:16Z |
| format | Article |
| id | doaj.art-2a2c1c8c94e64fafa87345fb441cc545 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T16:21:16Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-2a2c1c8c94e64fafa87345fb441cc5452023-11-20T13:36:43ZengMDPI AGAntioxidants2076-39212020-09-019985710.3390/antiox9090857Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of ActionInyong Jung0Hyerin Kim1Seongcheol Moon2Hyuk Lee3Bonglee Kim4College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, KoreaCollege of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, KoreaCollege of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, KoreaCollege of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, KoreaCollege of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, Korea<i>Salvia miltiorrhiza</i> Bunge (<i>S. miltiorrhiza</i>) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of <i>S. miltiorrhiza</i>, including inflammation, fibrosis, oxidative stress, and apoptosis. The findings on multi-functional properties of <i>S. miltiorrhiza</i> discussed in this article support the efficacy of <i>S. miltiorrhiza</i> extract on various diseases, but also call for further research on the multiple mechanisms that mediate its therapeutic effects.https://www.mdpi.com/2076-3921/9/9/857<i>Salvia miltiorrhiza</i> Bungedansamcancercardiovascular diseasesliver diseasesnervous system diseases |
| spellingShingle | Inyong Jung Hyerin Kim Seongcheol Moon Hyuk Lee Bonglee Kim Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action Antioxidants <i>Salvia miltiorrhiza</i> Bunge dansam cancer cardiovascular diseases liver diseases nervous system diseases |
| title | Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action |
| title_full | Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action |
| title_fullStr | Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action |
| title_full_unstemmed | Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action |
| title_short | Overview of <i>Salvia miltiorrhiza</i> as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action |
| title_sort | overview of i salvia miltiorrhiza i as a potential therapeutic agent for various diseases an update on efficacy and mechanisms of action |
| topic | <i>Salvia miltiorrhiza</i> Bunge dansam cancer cardiovascular diseases liver diseases nervous system diseases |
| url | https://www.mdpi.com/2076-3921/9/9/857 |
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