A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India
Background and Aims: The incidence of specific complications and adverse outcomes in dengue patients needing admission to intensive care units (ICU) may be quite variable in different regions of India presumably because of different strains of dengue virus or due to re infection. Methods: Patients a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2020;volume=64;issue=3;spage=181;epage=186;aulast=Shastri |
| _version_ | 1818839252599832576 |
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| author | Prakash S Shastri Prasoon Gupta Rahul Kumar |
| author_facet | Prakash S Shastri Prasoon Gupta Rahul Kumar |
| author_sort | Prakash S Shastri |
| collection | DOAJ |
| description | Background and Aims: The incidence of specific complications and adverse outcomes in dengue patients needing admission to intensive care units (ICU) may be quite variable in different regions of India presumably because of different strains of dengue virus or due to re infection. Methods: Patients admitted with acute febrile illness (AFI) with either positive IgM antibody or NS1 antigen for dengue were enrolled. Data were collected for 3 years (2015-2017). A total of 313 patients with acute febrile illness were admitted in the study period (2252 total ICU admissions). A total of 137 (43.76%) cases were serologically proven as dengue fever. Results: Median age (IQR) of study population was 36.0 (26.0–52.0) years. Liver (65.7%) was the main organ involved followed by acute kidney Injury (AKI) (18.6%). Dengue Shock Syndrome (DSS) was found in 18.6% of cases. Fifty-two patients died and the crude mortality was 38.0%. On multivariate analysis APACHE Score <10, thrombocytopenia, hepatic dysfunction, AKI and dengue shock syndrome (DSS) were associated with the risk of mortality. Conclusion: This study in ICU patients showed high mortality in relatively younger patients. Liver (in the form of raised Bilirubin) was the most common organ dysfunction. The need to recognise early warning signs for ICU admission is highlighted. |
| first_indexed | 2024-12-19T03:51:20Z |
| format | Article |
| id | doaj.art-2a2d30a99b7d4b82b4f3648d3f0325eb |
| institution | Directory Open Access Journal |
| issn | 0019-5049 0976-2817 |
| language | English |
| last_indexed | 2024-12-19T03:51:20Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-2a2d30a99b7d4b82b4f3648d3f0325eb2022-12-21T20:36:58ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50490976-28172020-01-0164318118610.4103/ija.IJA_865_19A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North IndiaPrakash S ShastriPrasoon GuptaRahul KumarBackground and Aims: The incidence of specific complications and adverse outcomes in dengue patients needing admission to intensive care units (ICU) may be quite variable in different regions of India presumably because of different strains of dengue virus or due to re infection. Methods: Patients admitted with acute febrile illness (AFI) with either positive IgM antibody or NS1 antigen for dengue were enrolled. Data were collected for 3 years (2015-2017). A total of 313 patients with acute febrile illness were admitted in the study period (2252 total ICU admissions). A total of 137 (43.76%) cases were serologically proven as dengue fever. Results: Median age (IQR) of study population was 36.0 (26.0–52.0) years. Liver (65.7%) was the main organ involved followed by acute kidney Injury (AKI) (18.6%). Dengue Shock Syndrome (DSS) was found in 18.6% of cases. Fifty-two patients died and the crude mortality was 38.0%. On multivariate analysis APACHE Score <10, thrombocytopenia, hepatic dysfunction, AKI and dengue shock syndrome (DSS) were associated with the risk of mortality. Conclusion: This study in ICU patients showed high mortality in relatively younger patients. Liver (in the form of raised Bilirubin) was the most common organ dysfunction. The need to recognise early warning signs for ICU admission is highlighted.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2020;volume=64;issue=3;spage=181;epage=186;aulast=Shastriacute physiology and chronic health evaluationdengue feverigmintensive care unitns1shocksequential organ failure assessment |
| spellingShingle | Prakash S Shastri Prasoon Gupta Rahul Kumar A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India Indian Journal of Anaesthesia acute physiology and chronic health evaluation dengue fever igm intensive care unit ns1 shock sequential organ failure assessment |
| title | A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India |
| title_full | A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India |
| title_fullStr | A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India |
| title_full_unstemmed | A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India |
| title_short | A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India |
| title_sort | prospective 3 year study of clinical spectrum and outcome of dengue fever in icu from a tertiary care hospital in north india |
| topic | acute physiology and chronic health evaluation dengue fever igm intensive care unit ns1 shock sequential organ failure assessment |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2020;volume=64;issue=3;spage=181;epage=186;aulast=Shastri |
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